Itraconazol Generis (Itraconazole)

Itraconazole blocks the fungal enzyme lanosterol 14α-demethylase, a member of the cytochrome P450 family. By inhibiting this enzyme, the drug prevents the synthesis of ergosterol, an essential component of fungal cell membranes, leading to membrane destabilisation and inhibition of fungal growth.

The dosage of Itraconazol Generis is determined by the prescribing clinician based on the specific infection, severity, patient weight, renal and hepatic function, and other individual factors. Healthcare professionals set the appropriate regimen and duration according to clinical guidelines.

Safety data for itraconazole in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Itraconazole is a triazole antifungal that offers broader coverage against molds such as Aspergillus compared with fluconazole, a fluoro‑triazole primarily effective against yeasts. Itraconazole has a longer half‑life and higher tissue penetration, but it also carries a higher risk of hepatic and cardiac adverse effects, requiring more careful monitoring.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not refrigerate or freeze the oral formulation, as temperature extremes may affect stability.

Itraconazol Generis is administered orally, usually with food or a full glass of water to enhance absorption. The tablet or capsule should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional. Follow the prescriber’s directions regarding timing and duration of therapy.

Serious risks include hepatic toxicity (elevated liver enzymes, hepatitis), severe skin reactions such as Stevens‑Johnson syndrome, congestive heart failure or worsening of existing heart failure, and significant drug‑drug interactions that can lead to arrhythmias or myopathy. Patients should report any unexplained jaundice, rash, shortness of breath, or swelling promptly.

Itraconazol Generis should be avoided in patients with known hypersensitivity to itraconazole or any azole antifungal, those with uncontrolled heart failure, and individuals taking contraindicated medications such as strong CYP3A4 inducers (e.g., rifampin, St. John’s wort). Caution is also advised for patients with severe hepatic impairment.