Product image of Itraconazol Viatris (Itraconazole) supplied by GNH India

Itraconazol Viatris

Active Ingredient:
Itraconazole
Origin:
EU

Itraconazol Viatris (Itraconazole)

Itraconazole, the active ingredient in Itraconazol Viatris, is a triazole antifungal presented as an oral formulation for systemic use. It is employed to treat a range of superficial and systemic mycotic infections in adult patients, including aspergillosis and histoplasmosis.

GNH India supplies Itraconazol Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance.

Manufacturer / TM Owner

Viatris Pharmaceuticals, S.L.U.

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Indications & Clinical Uses

Itraconazol Viatris is a triazole antifungal that targets invasive and superficial fungal infections.

  • Aspergillosis: treatment of invasive disease to eradicate the fungal pathogen.
  • Blastomycosis: eradication of systemic infection and prevention of relapse.
  • Histoplasmosis: management of acute and chronic forms of the disease.
  • Coccidioidomycosis: therapy for disseminated infection.
  • Dermatophytosis: resolution of skin fungal infections.
  • Systemic mycoses: broad‑spectrum control of deep fungal infections.

How It Works

  • Itraconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a cytochrome P450 isoform essential for converting lanosterol to ergosterol. By blocking ergosterol synthesis, the drug disrupts fungal cell membrane integrity, leading to impaired growth and eventual cell death.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Vomiting: occasional episodes after dosing.
  • Abdominal pain: discomfort in the stomach region.
  • Headache: transient mild headache.
  • Rash: skin irritation or mild erythema.
  • Taste disturbance: altered taste perception.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Congestive heart failure: fluid retention and reduced cardiac function.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • QT prolongation: cardiac rhythm disturbances.
  • Visual disturbances: blurred vision or photophobia.
  • Peripheral neuropathy: numbness or tingling in extremities.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Liver function monitoring: assess baseline and periodic liver enzymes.
  • Drug interaction review: evaluate concomitant medications for CYP3A4 interactions.
  • Cardiac assessment: screen for existing heart failure or edema.
  • Pregnancy: avoid use unless benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Itraconazole has a notable interaction profile that requires careful management.

Major Interactions (Avoid)

  • Rifampin: markedly reduces itraconazole plasma levels.
  • Ketoconazole: may increase toxicity due to additive CYP3A4 inhibition.
  • Macrolide antibiotics (e.g., erythromycin): can raise itraconazole concentrations.
  • Strong CYP3A4 inducers (e.g., carbamazepine): diminish therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Statins (e.g., simvastatin): heightened risk of myopathy.
  • Warfarin: potential alteration of anticoagulant response.
  • Oral contraceptives: possible reduction in efficacy.

Frequently Asked Questions

Itraconazol Viatris contains itraconazole, a triazole antifungal indicated for the treatment of a variety of superficial and systemic fungal infections, including aspergillosis, blastomycosis, histoplasmosis, coccidioidomycosis, dermatophytosis, and other deep mycoses.

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, an essential component of the fungal cell membrane. This disruption impairs membrane integrity, inhibiting fungal growth and leading to cell death.

The dosage of Itraconazol Viatris is determined by the prescribing clinician based on the specific infection, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here; the prescriber sets the appropriate dose.

Safety data for itraconazole in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with fluconazole, another triazole, itraconazole has a broader spectrum against molds such as Aspergillus and offers stronger activity against dimorphic fungi. However, itraconazole has a higher potential for drug‑drug interactions and may require therapeutic drug monitoring, whereas fluconazole is generally better tolerated but less effective against certain systemic infections.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not expose the medication to extreme heat or humidity.

Itraconazol Viatris is taken orally, usually with food or a full glass of water to improve absorption. The tablet or capsule should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious adverse events include hepatotoxicity (liver injury), congestive heart failure due to fluid retention, severe allergic reactions such as anaphylaxis, QT‑interval prolongation leading to cardiac arrhythmias, and rare visual disturbances. Patients should be monitored closely for signs of these conditions.

Itraconazol Viatris is contraindicated in patients with known hypersensitivity to itraconazole or any component of the formulation, and in individuals with a history of severe heart failure. Caution is also advised for patients with significant liver disease, uncontrolled arrhythmias, or those taking contraindicated interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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