Itraconazole Accord Healthcare (Itraconazole)

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol, a key component of the fungal cell membrane. Inhibiting this step disrupts membrane integrity, leading to increased permeability and ultimately fungal cell death.

The dosage of itraconazole is individualized by the prescribing clinician based on the specific infection, severity, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here; the prescriber determines the appropriate dose and duration.

Safety data for itraconazole during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant. Clinicians must evaluate the risk‑benefit ratio and discuss it with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with fluconazole, another azole antifungal, itraconazole has a broader spectrum covering many molds such as Aspergillus and dimorphic fungi, whereas fluconazole is more active against Candida species. Itraconazole also has a higher potential for drug‑drug interactions due to stronger CYP3A4 inhibition.

Itraconazole should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Itraconazole is taken orally, usually with food or a full glass of water to enhance absorption. The tablet or capsule should be swallowed whole and not crushed or chewed unless the formulation specifically allows it.

The most serious adverse events include hepatotoxicity (elevated liver enzymes, hepatitis, liver failure), congestive heart failure or worsening of existing heart failure, and cardiac arrhythmias such as QT prolongation. Patients should be monitored for signs of liver injury, shortness of breath, edema or palpitations.

Itraconazole is contraindicated in patients with known hypersensitivity to itraconazole or any azole antifungal, and in those with a history of severe heart failure. Caution is also advised for individuals with significant hepatic impairment, as the drug is metabolized by the liver.