Product image of Itraconazole Eg (Itraconazole) supplied by GNH India

Itraconazole Eg

Active Ingredient:
Itraconazole
Origin:
EU

Itraconazole Eg (Itraconazole)

Itraconazole, the active ingredient in Itraconazole Eg, is a Triazole antifungal presented as a unknown/unknown for oral use. It treats a range of fungal infections in both adult and pediatric patients as prescribed.

GNH India supplies Itraconazole Eg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

Itraconazole is a triazole antifungal that interferes with fungal cell membrane synthesis, making it effective for several mycotic conditions.

  • Dermatophyte infections: effective in treating skin fungal infections caused by dermatophytes.
  • Onychomycosis: promotes clearance of fungal nail disease.
  • Blastomycosis: used for systemic infection caused by Blastomyces dermatitidis.
  • Histoplasmosis: indicated for disseminated histoplasma infection.
  • Coccidioidomycosis: treats severe pulmonary or disseminated disease.
  • Aspergillosis: employed in chronic or invasive aspergillus infections.

How It Works

  • Itraconazole inhibits the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, blocking the conversion of lanosterol to ergosterol. This disruption impairs fungal cell membrane integrity, leading to inhibited growth and eventual death of susceptible fungi.

Side Effects

Adverse reactions may occur with itraconazole therapy.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Vomiting: occasional expulsion of stomach contents.
  • Abdominal pain: discomfort or cramps in the stomach area.
  • Headache: transient head pain.
  • Rash: skin redness or itching.
  • Taste alteration: dysgeusia or loss of taste.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac failure: worsening of congestive heart failure.
  • Visual disturbances: blurred vision or photophobia.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Hematologic abnormalities: neutropenia or thrombocytopenia.

Precautions & Warnings

Itraconazole requires careful monitoring and specific safety measures.

  • Liver function monitoring: assess hepatic enzymes before and during therapy.
  • Drug interaction assessment: review concomitant medications for potential interactions.
  • Pregnancy safety: avoid use in pregnancy unless benefits outweigh risks (Category D).
  • Hepatic impairment dose adjustment: modify dose in patients with liver disease.
  • Cardiac caution: use cautiously in patients with existing heart failure.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Itraconazole can affect the metabolism of several co‑administered drugs.

Major Interactions (Avoid)

  • Rifampin: strong enzyme inducer that reduces itraconazole levels.
  • St. John’s wort: herbal inducer leading to decreased efficacy.
  • Ketoconazole: concurrent use may increase toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Statins (e.g., simvastatin): increased risk of myopathy; dose adjustment may be needed.
  • Calcium channel blockers: may require dose modification.
  • Oral contraceptives: efficacy may be reduced, consider alternative contraception.

Frequently Asked Questions

Itraconazole Eg is prescribed for a variety of fungal infections, including dermatophyte skin infections, onychomycosis (fungal nail disease), and systemic mycoses such as blastomycosis, histoplasmosis, coccidioidomycosis, and aspergillosis. It works by targeting the fungal cell membrane, making it effective across these indications.

Itraconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to inhibited growth and eventual death of susceptible fungi.

The dosage of Itraconazole Eg is individualized by the prescribing clinician based on the specific infection, patient weight, age, liver function, and other clinical factors. Only a qualified healthcare professional should determine the appropriate regimen.

Itraconazole is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should be avoided during pregnancy unless the potential benefit justifies the risk. Use while breastfeeding is not recommended because the drug is excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with azole alternatives such as fluconazole, itraconazole has a broader spectrum against dermatophytes and certain systemic fungi, but it also has a higher potential for drug‑drug interactions due to CYP3A4 inhibition. Choice of therapy depends on the pathogen, infection site, and patient-specific factors.

Store Itraconazole Eg at temperatures below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Maintaining these conditions helps preserve the drug’s stability and potency.

Itraconazole Eg is taken orally, usually with food to enhance absorption. The exact administration instructions, including whether it should be taken with a full glass of water or any specific timing, are provided by the prescribing clinician.

Serious risks include hepatotoxicity (liver injury), severe skin reactions such as Stevens‑Johnson syndrome, cardiac failure exacerbation, and rare visual disturbances. Patients should be monitored for signs of liver dysfunction, rash, or cardiac symptoms during treatment.

Itraconazole should be avoided in patients with known hypersensitivity to itraconazole or other triazoles, in those with severe hepatic impairment, and in individuals with uncontrolled heart failure. Pregnant women should only use it if the potential benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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