Itraconazole/Kleva (Itraconazole)

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol, a critical component of the fungal cell membrane. Inhibiting this step disrupts membrane integrity, leading to impaired fungal growth and eventual cell death, while sparing human cells because the target enzyme is fungal‑specific.

The dosage of Itraconazole/Kleva is determined by the prescribing clinician based on the specific infection, severity, patient weight, renal and hepatic function, and other individual factors. Healthcare professionals follow established guidelines and adjust the regimen as needed; patients should follow the prescriber’s instructions precisely.

Safety data for itraconazole in pregnancy and lactation are limited, and the drug is generally classified as contraindicated unless the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and risk assessment with their healthcare provider before starting therapy.

To request Itraconazole/Kleva, visit the product page on gnhindia.com, enter the desired quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Itraconazole belongs to the triazole class and offers broader spectrum activity against dermatophytes and many systemic fungi compared with fluconazole, which is less effective for certain molds and dimorphic fungi. Itraconazole also has a longer half‑life, allowing once‑daily dosing for many indications, but it carries a higher potential for drug‑drug interactions due to CYP3A4 inhibition.

Store Itraconazole/Kleva at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat, and direct sunlight. Do not refrigerate or freeze the tablets or capsules, as this could affect their stability and efficacy.

Itraconazole/Kleva is taken orally, usually with food or a full glass of water to enhance absorption. The exact administration instructions, such as whether to take it with a high‑fat meal, depend on the formulation and the prescriber’s guidance. Patients should swallow tablets or capsules whole and avoid crushing them unless directed otherwise.

Serious adverse events include hepatotoxicity, which may present as elevated liver enzymes or hepatitis, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Cardiac failure can also occur, particularly in patients with pre‑existing heart disease. Prompt medical attention is required if any signs of liver injury, severe rash, or breathing difficulties develop.

Itraconazole/Kleva is contraindicated in patients with known hypersensitivity to itraconazole or any triazole antifungal. It should also be avoided in individuals with uncontrolled congestive heart failure, severe liver impairment, or those taking medications that strongly induce CYP3A4 (e.g., rifampin) without appropriate dose adjustments. Clinicians must evaluate each patient’s medical history before prescribing.