Itraconazole Sandoz Ltd (Itraconazole)

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol. By preventing ergosterol synthesis, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and inhibition of fungal growth and replication.

The specific dose and duration of itraconazole therapy are determined by the prescribing clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and other individual factors. Patients should follow the exact regimen provided by their healthcare provider.

Safety data for itraconazole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives and risks with their healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Itraconazole offers a broad spectrum of activity against many yeasts and molds and has a longer half‑life than some alternatives, allowing once‑daily dosing for certain indications. Compared with fluconazole, itraconazole provides better coverage for dermatophytes and some dimorphic fungi but may have a higher potential for drug interactions and liver‑related adverse effects.

Store the tablets at room temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light. Do not store in humid environments such as bathrooms, and keep out of reach of children.

Itraconazole Sandoz Ltd is taken orally, usually with food to enhance absorption, unless the prescribing information specifies otherwise. The tablets should be swallowed whole with a full glass of water and not chewed or crushed, unless a liquid formulation is prescribed.

Serious risks include hepatotoxicity, which may present as jaundice or elevated liver enzymes, and severe cardiac effects such as heart failure in susceptible patients. Rare but life‑threatening skin reactions like Stevens‑Johnson syndrome and toxic epidermal necrolysis can also occur. Patients should seek immediate medical attention if they notice signs of liver injury or severe skin rash.

Itraconazole is contraindicated in patients with known hypersensitivity to itraconazole or any azole antifungal. It should be avoided in individuals with severe liver disease, uncontrolled heart failure, or those taking medications that are strong inducers of CYP3A4 (e.g., rifampin, St. John's wort) without appropriate monitoring.