Product image of Itraconazole Viatris (Itraconazole) supplied by GNH India

Itraconazole Viatris

Active Ingredient:
Itraconazole
Origin:
EU

Itraconazole Viatris (Itraconazole)

Itraconazole, the active ingredient in Itraconazole Viatris, is a triazole antifungal presented as an oral formulation for oral use. It treats a range of systemic and superficial fungal infections, including dermatophytosis, onychomycosis, blastomycosis, histoplasmosis, aspergillosis and candidiasis, in patients for whom antifungal therapy is indicated.

GNH India supplies Itraconazole Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved products to health‑care institutions across multiple regions.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

Itraconazole is a triazole antifungal used to treat a variety of mycotic infections by inhibiting ergosterol synthesis.

  • Dermatophytosis: clears skin lesions by reducing fungal growth.
  • Onychomycosis: eradicates nail‑bed infection and promotes healthy nail regrowth.
  • Blastomycosis: eliminates systemic Blastomyces organisms and resolves pulmonary involvement.
  • Histoplasmosis: controls disseminated Histoplasma infection in affected organs.
  • Aspergillosis: suppresses invasive Aspergillus species in immunocompromised patients.
  • Candidiasis: treats mucosal and systemic Candida infections.

How It Works

  • Itraconazole inhibits the fungal cytochrome P450 enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking this pathway, the drug disrupts fungal cell membrane formation, leading to increased membrane permeability and inhibition of fungal growth.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools, often self‑limiting.
  • Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Cardiac failure: signs of reduced heart function, especially in high‑risk patients.
  • Severe skin reactions: rash, Stevens‑Johnson syndrome, or toxic epidermal necrolysis.

Precautions & Warnings

Itraconazole requires careful monitoring due to its pharmacologic profile.

  • Monitor liver function: baseline and periodic tests are recommended because of potential hepatotoxicity.
  • Assess cardiac status: avoid in patients with existing heart failure or significant ventricular dysfunction.
  • Review concomitant medications: many drugs affect or are affected by CYP3A4 metabolism.
  • Pregnancy and lactation: use only if the potential benefit outweighs the risk, as safety data are limited.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Itraconazole has a notable interaction profile that clinicians must consider.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce itraconazole exposure.
  • Certain antiarrhythmics (e.g., quinidine): can increase risk of cardiac toxicity.

Moderate Interactions (Monitor Closely)

  • Statins metabolized by CYP3A4 (e.g., simvastatin): may raise statin levels, increasing myopathy risk.
  • Proton pump inhibitors: may decrease itraconazole absorption; assess timing of administration.
  • Anticoagulants (e.g., warfarin): may require INR monitoring due to altered metabolism.

Frequently Asked Questions

Itraconazole Viatris is prescribed for a range of fungal infections, including skin and nail conditions such as dermatophytosis and onychomycosis, as well as systemic diseases like blastomycosis, histoplasmosis, aspergillosis and candidiasis. The specific indication depends on the clinical assessment of the treating physician.

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. By inhibiting this step, the drug compromises membrane integrity, leading to impaired growth and eventual death of the fungal cells.

The dosage of Itraconazole Viatris is determined by the prescribing clinician based on the type and severity of the infection, patient age, weight, liver function and other individual factors. Only a qualified health‑care professional should set the dosing regimen.

Safety data for itraconazole in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a health‑care provider.

To request Itraconazole Viatris, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itraconazole belongs to the triazole class, which generally offers oral dosing convenience and broad-spectrum activity against many yeasts and molds. Compared with polyenes such as amphotericin B, itraconazole is less nephrotoxic but may have more drug‑interaction potential due to CYP3A4 metabolism.

Itraconazole Viatris should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Itraconazole Viatris is taken orally, usually with food or an acidic beverage to enhance absorption. The tablet or capsule should be swallowed whole with a full glass of water, and the dosing schedule set by the prescriber should be followed precisely.

Serious adverse events can include liver injury, heart failure, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of hepatic dysfunction, cardiac symptoms, or rash, and any concerning symptoms should be reported to a health‑care professional promptly.

Itraconazole Viatris is contraindicated in patients with known hypersensitivity to itraconazole or any triazole antifungal, and it should be avoided in individuals with severe heart failure. Caution is also advised for patients with significant liver impairment or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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