Itrazol (Itraconazole)

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase (CYP51), which is essential for converting lanosterol to ergosterol, a key component of the fungal cell membrane. Inhibiting this step disrupts membrane integrity, leading to increased permeability and ultimately halting fungal growth.

The specific dose of Itrazol is determined by the prescribing clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and other individual factors. Only a qualified health professional should set the dosing regimen.

Safety data for itraconazole in pregnancy are limited, and the drug is classified as pregnancy category unknown. It should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their physician, as itraconazole may be excreted in milk.

To place an order, submit an enquiry on the Itrazol product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Itrazol (itraconazole) offers a broad spectrum of activity against dermatophytes, yeasts and dimorphic fungi, and it has a longer half‑life than fluconazole, allowing once‑daily dosing for many indications. However, it has a higher potential for drug‑drug interactions due to strong CYP3A4 inhibition, which may require more careful monitoring compared with agents like fluconazole.

Itrazol should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Itrazol is taken orally, usually with a full glass of water. The tablet or capsule should be swallowed whole and not crushed or chewed. Food can affect absorption, so patients should follow the specific instructions provided by their prescriber regarding intake with meals.

The most serious risks include hepatotoxicity, which may present as elevated liver enzymes or liver failure, and cardiac failure, particularly in patients with pre‑existing heart disease. Severe skin reactions such as Stevens‑Johnson syndrome and visual disturbances have also been reported, requiring immediate medical attention.

Itrazol is contraindicated in patients with known hypersensitivity to itraconazole or any azole antifungal. It should also be avoided in individuals with severe liver impairment, uncontrolled heart failure, or those taking medications that are strong CYP3A4 inducers such as rifampin or St. John’s wort, unless a specialist advises otherwise.