Product image of Ivabradin Hcs (Ivabradine) supplied by GNH India

Ivabradin Hcs

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradin Hcs (Ivabradine)

Ivabradine, the active ingredient in Ivabradin Hcs, is a If (funny) channel inhibitor presented as a tablet for oral use. It treats chronic stable angina pectoris and heart failure with reduced ejection fraction in appropriate patients.

GNH India supplies Ivabradin Hcs as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hcs Bvba

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ivabradin Hcs is indicated for conditions where reduction of heart rate improves clinical outcomes.

  • Chronic stable angina pectoris: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction (NYHA class II–III): improves exercise capacity and lowers the risk of hospitalization through heart‑rate reduction.

How It Works

  • Ivabradine selectively inhibits the cardiac pacemaker If current in the sino‑atrial node. By blocking this mixed sodium‑potassium inward current, the drug slows spontaneous depolarisation of pacemaker cells, producing a dose‑dependent reduction in heart rate without affecting myocardial contractility or ventricular repolarisation.

Side Effects

Adverse reactions may occur with ivabradine therapy.

Common Side Effects

  • Visual disturbances (phosphenes)
  • Headache
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Severe bradycardia
  • Atrial fibrillation
  • Symptomatic hypotension

Precautions & Warnings

Use ivabradine with careful clinical monitoring.

  • Heart rate monitoring: assess baseline and periodic heart rate to avoid excessive bradycardia.
  • Concomitant beta‑blockers: avoid combined use unless clinically justified.
  • Severe hepatic impairment: use with caution or avoid.
  • Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradine may interact with several medicines.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine plasma concentrations.
  • Other heart‑rate‑lowering agents (e.g., beta‑blockers, digoxin): risk of severe bradycardia.

Moderate Interactions (Monitor Closely):\n- Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may require dose adjustment.

  • CYP3A4 inducers (e.g., rifampicin): may reduce ivabradine efficacy.
  • Certain anti‑arrhythmic drugs (e.g., amiodarone): monitor heart‑rate response.

Frequently Asked Questions

Ivabradin Hcs contains ivabradine, which is prescribed to lower heart rate in patients with chronic stable angina pectoris and in those with heart failure with reduced ejection fraction (NYHA class II–III). By reducing heart rate, it helps relieve angina symptoms and improves functional capacity in heart‑failure patients.

Ivabradine selectively blocks the If (funny) current in the sino‑atrial node, the primary pacemaker of the heart. Inhibition of this mixed sodium‑potassium inward current slows the spontaneous depolarisation of pacemaker cells, producing a controlled reduction in heart rate without decreasing myocardial contractility.

The dosage of ivabradine is individualized by the prescribing clinician based on the patient’s heart‑rate, clinical condition, and tolerability. Typical regimens start with a low dose that may be titrated upward, but the exact amount and schedule must be determined by a qualified healthcare professional.

Safety data for ivabradine during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential maternal benefit justifies any possible risk to the fetus, and breastfeeding mothers should consult their physician before use.

To request Ivabradin Hcs, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but they act via different mechanisms. Beta‑blockers reduce heart rate by blocking adrenergic receptors and also decrease contractility, whereas ivabradine selectively inhibits the If current without affecting contractility. Ivabradine is often considered when beta‑blockers are contraindicated or insufficient.

Store Ivabradin Hcs at ambient temperature below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Ivabradin Hcs is taken orally, usually with a glass of water. The tablet should be swallowed whole and not split, crushed, or chewed. Dosing times are generally spaced evenly, often twice daily, but the exact schedule is set by the prescribing clinician.

The most serious adverse events include severe bradycardia, atrial fibrillation, and symptomatic hypotension. Patients should be instructed to report any unusually slow heartbeat, faintness, dizziness, or palpitations promptly, as these may require medical evaluation or dose adjustment.

Ivabradine is contraindicated in patients with acute decompensated heart failure, severe hypotension, sick sinus syndrome, or permanent atrial fibrillation. It should also be avoided in individuals with known hypersensitivity to ivabradine or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.