Product image of Ivabradin Heumann (Ivabradine Hydrochloride) supplied by GNH India

Ivabradin Heumann

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradin Heumann (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradin Heumann, is a If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradin Heumann as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Heumann Pharma Gmbh & Co. Generica Kg

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Indications & Clinical Uses

Ivabradin Heumann acts on the cardiac If channel to manage conditions where heart‑rate reduction is therapeutic.

  • Chronic stable angina: decreases the frequency of angina attacks by lowering heart rate without affecting contractility.
  • Heart failure with reduced ejection fraction: improves symptoms and may reduce hospitalisation by controlling heart rate.
  • Stable coronary artery disease: provides symptomatic relief of exertional chest pain through heart‑rate modulation.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node. By blocking this pacemaker current, it reduces spontaneous depolarisation, leading to a slower heart rate while preserving myocardial contractility and blood pressure, which helps alleviate angina and improves ventricular filling in heart failure.

Side Effects

Ivabradin Heumann may cause a range of adverse reactions.

Common Side Effects

  • Bradycardia: heart rate slower than intended.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Nausea.

Serious or Rare Side Effects

  • Severe bradycardia requiring medical intervention.
  • Atrial fibrillation or other arrhythmias.
  • Symptomatic hypotension.
  • Persistent visual loss.
  • Allergic reactions such as rash or angioedema.

Precautions & Warnings

Before prescribing Ivabradin Heumann, clinicians should consider several safety measures.

  • Cardiac monitoring: assess baseline heart rate and rhythm.
  • Concomitant beta‑blockers: avoid excessive bradycardia by adjusting doses.
  • Severe hepatic impairment: use with caution, dose may need adjustment.
  • Pregnancy: safety unknown; avoid unless benefit outweighs risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradin Heumann can interact with other medicines that affect heart rate or its metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine plasma levels.
  • Other heart‑rate‑lowering agents (e.g., digoxin, beta‑blockers): risk of severe bradycardia.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce ivabradine effectiveness.
  • Antihypertensives: monitor blood pressure for additive effects.
  • Antacids containing aluminum or magnesium: may decrease ivabradine absorption if taken simultaneously.

Frequently Asked Questions

Ivabradin Heumann contains ivabradine, which is prescribed to lower heart rate in adults with chronic stable angina and in patients with heart failure whose left‑ventricular ejection fraction is reduced. By slowing the heart rate, it helps relieve chest pain during exertion and can improve symptoms of heart failure.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. This inhibition reduces the rate of spontaneous depolarisation, leading to a slower heart rate while leaving contractility and blood pressure largely unchanged, which is useful in angina and certain heart‑failure states.

The exact dose of Ivabradin Heumann is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate response, and tolerance. Physicians typically start with a low dose and titrate upward as needed, following local prescribing guidelines and monitoring parameters.

Safety data for ivabradine during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and a healthcare professional should evaluate each case individually.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to ivabradine for heart‑rate reduction is the beta‑blocker class. Unlike beta‑blockers, ivabradine lowers heart rate without affecting myocardial contractility or blood pressure, making it useful when beta‑blockers are contraindicated or not tolerated. However, beta‑blockers also provide anti‑ischemic and anti‑arrhythmic benefits that ivabradine does not.

Store Ivabradin Heumann at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain product stability.

Ivabradin Heumann is administered orally as a tablet. It can be taken with or without food, but patients should follow the prescribing physician’s instructions regarding timing relative to meals to ensure consistent absorption.

The most serious risks include severe bradycardia that may cause dizziness or syncope, atrial fibrillation or other arrhythmias, and rare visual disturbances such as persistent loss of vision. Patients should report any episodes of fainting, rapid irregular heartbeats, or new visual symptoms to their healthcare provider promptly.

Ivabradin Heumann should be avoided in patients with a resting heart rate below 60 bpm, those with sick‑sinus syndrome, acute decompensated heart failure, severe hypotension, or known hypersensitivity to ivabradine or any excipients. It is also contraindicated in combination with certain strong CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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