Product image of Ivabradin Heumann (Ivabradine Oxalate) supplied by GNH India

Ivabradin Heumann

Active Ingredient:
Ivabradine Oxalate
Origin:
EU

Ivabradin Heumann (Ivabradine Oxalate)

Ivabradine, the active ingredient in Ivabradin Heumann, is a If channel inhibitor presented as an oral tablet for oral use. It treats chronic stable angina pectoris and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradin Heumann as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Heumann Pharma Gmbh & Co. Generica Kg

1
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Indications & Clinical Uses

  • Ivabradine acts on the cardiac If current to manage specific cardiovascular conditions.
  • Chronic stable angina pectoris: reduces the frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers heart rate, enhancing functional capacity and decreasing hospitalization risk.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows spontaneous depolarization. This reduction in pacemaker activity lowers heart rate without affecting myocardial contractility or systemic blood pressure, helping to relieve myocardial oxygen demand in angina and improve hemodynamics in heart failure.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Visual disturbances (phosphenes) or blurred vision.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Mild bradycardia.
  • Nausea.

Serious or Rare Side Effects

  • Severe bradycardia requiring medical attention.
  • Atrial fibrillation or other arrhythmias.
  • Symptomatic hypotension.
  • Heart block.
  • Visual loss.
  • Severe allergic reactions (anaphylaxis).

Precautions & Warnings

  • Careful assessment and monitoring are required before and during therapy.
  • Cardiac monitoring: obtain baseline heart rate and ECG before initiation.
  • Contraindication in severe hepatic impairment: avoid use due to altered metabolism.
  • Caution in sick sinus syndrome: increased risk of excessive bradycardia.
  • Avoid concomitant strong CYP3A4 inhibitors: may raise plasma levels.
  • Pregnancy and lactation: risk unknown; use only if clearly needed.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradine can interact with several drug classes, altering its effect on heart rate.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): risk of marked bradycardia.
  • Other heart‑rate‑lowering agents (e.g., beta‑blockers): may cause severe bradycardia.
  • AV‑node blockers (e.g., diltiazem, verapamil): increase ivabradine exposure.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, clarithromycin): monitor heart rate.
  • Digoxin: watch for additive bradycardic effect.
  • Antihypertensives: possible enhanced hypotensive response.

Frequently Asked Questions

Ivabradin Heumann contains ivabradine, which is indicated for chronic stable angina pectoris and for heart failure with reduced ejection fraction. In both conditions the drug lowers heart rate, helping to reduce chest pain episodes and improve functional capacity.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. By inhibiting this current, the drug slows the spontaneous depolarisation of pacemaker cells, resulting in a reduced heart rate without affecting contractility or blood pressure.

The specific dose of Ivabradin Heumann is determined by the prescribing clinician based on the patient’s clinical condition, heart rate, and response to therapy. Dosage adjustments are made according to individual therapeutic goals and tolerability.

The safety of ivabradine in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on beta‑adrenergic receptors and also reduce contractility and blood pressure, which may be advantageous or limiting depending on the patient’s overall cardiovascular profile.

Ivabradin Heumann should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency.

Ivabradin Heumann is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. Administration timing and frequency are set by the prescribing clinician according to the patient’s therapeutic needs.

The most serious risks include severe bradycardia, atrial fibrillation, symptomatic hypotension, heart block, and rare visual disturbances that may lead to vision loss. Patients should be monitored for these events, especially during dose initiation and when combined with other heart‑rate‑lowering agents.

Ivabradin Heumann is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, or those with a resting heart rate below 50 beats per minute. It should also be avoided in individuals taking strong CYP3A4 inhibitors unless the prescriber decides otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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