Product image of Ivabradin Krka (Ivabradine) supplied by GNH India

Ivabradin Krka

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradin Krka (Ivabradine)

Ivabradine, the active ingredient in Ivabradin Krka, is a If channel inhibitor presented as an oral dosage form for oral use. It reduces heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients. It provides heart‑rate lowering without affecting myocardial contractility.

GNH India supplies Ivabradin Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics across global markets, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Ivabradin Krka (ivabradine) acts on the cardiac If channel to manage ischemic heart disease and heart failure.

  • Chronic stable angina: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction: improves symptoms and may lower hospitalization risk by decreasing heart rate.
  • Exercise‑induced angina: facilitates increased exercise tolerance by maintaining lower heart rates during activity.

How It Works

  • Ivabradine selectively blocks the funny (If) current in the sinoatrial node by binding to the channel pore, slowing spontaneous depolarisation of pacemaker cells. This produces a heart‑rate reduction while leaving myocardial contractility, atrioventricular conduction and blood pressure largely unchanged. The drug does not interact with beta‑adrenergic receptors or calcium channels, allowing a heart‑rate specific effect that can be combined with other cardiovascular therapies.

Side Effects

Ivabradine may be associated with several adverse reactions, ranging from frequent to rare.

Common Side Effects

  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Bradycardia: slower than intended heart rate.
  • Headache: mild to moderate intensity.
  • Dizziness: especially on standing.

Serious or Rare Side Effects

  • Atrial fibrillation: new‑onset arrhythmia.
  • Severe bradycardia requiring intervention.
  • Hypotension: marked blood pressure drop.
  • Allergic reactions: rash, angioedema, anaphylaxis.

Precautions & Warnings

Before prescribing Ivabradin Krka, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate baseline heart rate and rhythm prior to initiation.
  • Concomitant beta‑blockers: avoid excessive heart‑rate reduction when combined with other rate‑lowering agents.
  • CYP3A4 inhibitors: adjust therapy if strong inhibitors are used concurrently.
  • Visual disturbances: advise patients to report persistent luminous phenomena.
  • Pregnancy and breastfeeding: use only if clearly needed and prescribed by a specialist.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Ivabradine interacts with several drug classes; careful review is required.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine plasma levels.
  • Concomitant bradycardic agents (e.g., beta‑blockers, digoxin, diltiazem, verapamil): risk of excessive heart‑rate reduction.
  • Pacemaker dependence: ivabradine may be ineffective or cause bradyarrhythmia.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole, erythromycin): may modestly raise concentrations.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Antihypertensives: monitor blood pressure for additive effects.

Frequently Asked Questions

Ivabradin Krka contains ivabradine, which is prescribed to lower heart rate in adults with chronic stable angina and in patients with heart failure that has a reduced ejection fraction. By slowing the heart’s pacing, it helps relieve angina symptoms and can improve functional status in heart‑failure patients.

Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. Blocking this current slows the spontaneous depolarisation of pacemaker cells, leading to a reduction in heart rate while leaving contractility, blood pressure and conduction largely unchanged.

The dose of Ivabradin Krka is individualized by the prescribing clinician based on the patient’s heart‑rate, clinical condition and concomitant therapies. The prescriber determines the appropriate starting dose, titration schedule and maintenance dose according to current clinical guidelines.

Ivabradine is generally avoided during pregnancy and lactation unless the potential benefit justifies the risk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative therapies with their healthcare provider.

To order Ivabradin Krka, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but they act via different mechanisms. Beta‑blockers block adrenergic receptors and also reduce contractility and blood pressure, whereas ivabradine selectively targets the If current without affecting contractility. This makes ivabradine a useful add‑on when additional rate control is needed without further lowering blood pressure.

Store Ivabradin Krka at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct light, and ensure the packaging remains tightly closed until use.

Ivabradin Krka is taken orally, usually with a glass of water. The tablet should be swallowed whole and not split, crushed or chewed. Dosing times are typically spaced evenly, often twice daily, but the exact schedule is set by the prescribing clinician.

The most serious risks include severe bradycardia, atrial fibrillation, marked hypotension and allergic reactions such as rash, angioedema or anaphylaxis. Patients should seek immediate medical attention if they experience fainting, rapid irregular heartbeats, severe dizziness, or signs of an allergic response.

Ivabradin Krka should not be used by patients with a resting heart rate below 50 beats per minute, those with severe hepatic impairment, or individuals who are dependent on a pacemaker for rhythm control. It is also contraindicated in patients taking strong CYP3A4 inhibitors without dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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