Product image of Ivabradin Medical Valley (Ivabradine) supplied by GNH India

Ivabradin Medical Valley

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradin Medical Valley (Ivabradine)

Ivabradine, the active ingredient in Ivabradin Medical Valley, is a If channel inhibitor presented as an oral formulation for oral use. It treats chronic stable angina and heart failure with reduced ejection fraction in adult patients. \nGNH India supplies Ivabradin Medical Valley as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medical Valley Invest Ab

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Indications & Clinical Uses

  • Ivabradin Medical Valley acts on the cardiac conduction system to lower heart rate, benefiting several cardiovascular conditions.\n\nChronic stable angina: reduces the frequency of angina attacks by decreasing myocardial oxygen demand.\nHeart failure with reduced ejection fraction: improves symptoms and lowers the risk of hospitalization.\nStable coronary artery disease: lowers heart rate to enhance exercise tolerance.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which controls spontaneous depolarisation. By blocking this inward sodium‑potassium current, the drug slows the pacemaker activity, producing a dose‑dependent reduction in heart rate without compromising myocardial contractility or blood pressure.

Side Effects

  • Ivabradin Medical Valley may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.\n\nCommon Side Effects:\n- Phosphenes (luminous visual phenomena)\n- Bradycardia\n- Headache\n- Dizziness\n\nSerious or Rare Side Effects:\n- Severe bradyarrhythmia\n- Atrioventricular block\n- Worsening heart failure\n- Marked hypotension

Precautions & Warnings

  • Before prescribing Ivabradin Medical Valley, clinicians should consider several safety measures.\n- Assess baseline heart rate: ensure resting HR ≥ 60 bpm before initiation.\n- Avoid strong CYP3A4 inhibitors: may raise plasma concentrations.\n- Monitor for symptomatic bradycardia: adjust dose if needed.\n- Use with caution in severe hepatic impairment.\n- Discontinue before elective cardiac surgery to avoid peri‑operative bradycardia.\n- Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

  • Ivabradin Medical Valley can interact with other medicines, requiring careful management.\n\nMajor Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): risk of excessive bradycardia.\n- Co‑administration with other heart‑rate‑lowering agents (beta‑blockers, digoxin): may cause severe bradycardia.\n- Other If channel inhibitors: additive effect on heart rate.\n\nModerate Interactions (Monitor Closely):\\n- Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may increase drug levels, monitor HR.\n- QT‑prolonging drugs: monitor ECG for arrhythmia risk.\n- Certain antidepressants affecting CYP3A4 (e.g., sertraline): observe for heart‑rate changes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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