Product image of Ivabradin Medical Valley (Ivabradine) supplied by GNH India

Ivabradin Medical Valley

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradin Medical Valley (Ivabradine)

Ivabradine, the active ingredient in Ivabradin Medical Valley, is a If channel inhibitor presented as an oral formulation for oral use. It lowers heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradin Medical Valley as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medical Valley Invest Ab

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Indications & Clinical Uses

  • Ivabradine acts on the cardiac If current to control heart rate in several cardiovascular conditions.
  • Chronic stable angina: reduces the frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers heart rate, improves symptoms and may reduce hospitalisations.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows spontaneous depolarisation. By reducing the pacemaker activity without affecting myocardial contractility, the drug lowers heart rate while preserving cardiac output and blood pressure.

Side Effects

Ivabradine may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Visual disturbances (phosphenes or luminous phenomena)
  • Bradycardia (slow heart rate)
  • Headache
  • Dizziness
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Severe bradycardia requiring medical attention
  • Atrial fibrillation or other arrhythmias
  • Symptomatic hypotension
  • Persistent visual impairment
  • Severe allergic reactions (rash, angioedema)

Precautions & Warnings

  • Before initiating ivabradine, clinicians should consider several safety factors.
  • Cardiac monitoring: assess baseline heart rate and rhythm.
  • Concomitant beta‑blockers: avoid excessive bradycardia by adjusting doses.
  • CYP3A4 inhibitors: dose may need reduction when strong inhibitors are used.
  • Renal or hepatic impairment: use with caution and monitor response.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Ivabradine interacts with several medicines that affect heart rate or its metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase ivabradine exposure.
  • Concomitant bradycardic agents (beta‑blockers, digoxin): risk of severe bradycardia.
  • Other If channel inhibitors (e.g., ranolazine): additive heart‑rate lowering.

Moderate Interactions (Monitor Closely):\n- Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may raise plasma levels.

  • QT‑prolonging drugs: monitor ECG for arrhythmia risk.
  • Excess alcohol: can enhance bradycardic effect.

Frequently Asked Questions

Ivabradin Medical Valley contains ivabradine, which is prescribed to lower heart rate in adults with chronic stable angina and in patients with heart failure with reduced ejection fraction. By reducing the heart rate, it helps relieve angina symptoms and may improve functional capacity in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, the heart’s natural pacemaker. Inhibiting this current slows the spontaneous depolarisation of pacemaker cells, leading to a reduced heart rate without decreasing the strength of cardiac contraction or blood pressure.

The specific dose of Ivabradin Medical Valley is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate targets, and any concomitant therapies. Dosage adjustments are made according to individual response and tolerability.

Safety data for ivabradine in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but they act via different mechanisms. Ivabradine selectively inhibits the If current without affecting myocardial contractility or blood pressure, whereas beta‑blockers block adrenergic receptors and can also reduce contractility. Ivabradine is often used when beta‑blockers are contraindicated or insufficient.

Store Ivabradin Medical Valley at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Ivabradin Medical Valley is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. Dosing times are typically spaced to maintain consistent plasma concentrations, as directed by the prescribing physician.

The most serious risks include severe bradycardia, which can lead to dizziness, syncope or heart‑failure worsening, and atrial fibrillation or other arrhythmias. Persistent visual disturbances and rare allergic reactions are also considered serious and require immediate medical evaluation.

Ivabradine should be avoided in patients with a resting heart rate below 60 bpm, those with acute decompensated heart failure, severe hypotension, sick sinus syndrome, or advanced atrioventricular block without a pacemaker. It is also contraindicated in individuals taking strong CYP3A4 inhibitors without dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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