Product image of Ivabradin Stada (Ivabradine Hydrochloride) supplied by GNH India

Ivabradin Stada

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradin Stada (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradin Stada, is an If channel inhibitor presented as an oral tablet for oral use. It is indicated for chronic stable angina pectoris and for heart failure with reduced ejection fraction, helping to lower heart rate without affecting contractility in adult patients.

GNH India supplies Ivabradin Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is manufactured for the EU market and meets European quality standards and is distributed under strict regulatory oversight.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Ivabradin Stada (ivabradine) acts on the cardiac sinus node to reduce heart rate, and is used in the following cardiovascular conditions:

  • Chronic stable angina pectoris: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction: improves symptoms and may lower hospitalization risk by decreasing heart rate.
  • Patients intolerant to beta‑blockers with chronic angina: provides heart‑rate control when beta‑blockers are unsuitable.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows the spontaneous depolarisation of pacemaker cells. By reducing this inward sodium/potassium current, the drug lowers the resting heart rate without impairing myocardial contractility or blood pressure, thereby improving cardiac efficiency in conditions where heart‑rate reduction is therapeutic.

Side Effects

Ivabradin Stada may cause a range of adverse reactions. Patients should be aware of both frequent and less common events.

Common Side Effects

  • Bradycardia: abnormally slow heart rate.
  • Phosphenes: transient luminous phenomena in the visual field.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Visual blur.

Serious or Rare Side Effects

  • Atrial fibrillation.
  • Severe bradycardia leading to syncope.
  • Significant hypotension.
  • Vision loss (rare).
  • Cardiac arrest (extremely rare).

Precautions & Warnings

When prescribing Ivabradin Stada, clinicians should consider several safety measures.

  • Baseline heart rate assessment: ensure resting heart rate is ≥ 50 bpm before initiation.
  • Contraindicated in acute decompensated heart failure.
  • Use caution in patients with hepatic impairment; dose adjustment may be required.
  • Monitor for symptomatic bradycardia during therapy.
  • Avoid concomitant strong CYP3A4 inhibitors without dose modification.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ivabradin Stada can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may markedly increase ivabradine exposure.
  • Concomitant bradycardic agents (e.g., beta‑blockers, digoxin): risk of excessive heart‑rate reduction.
  • Other If channel inhibitors (e.g., ranolazine): additive effect on heart‑rate lowering.

Moderate Interactions (Monitor Closely):\n- Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may modestly raise plasma levels.

  • Drugs that prolong the QT interval: monitor ECG for arrhythmia risk.
  • Smoking: induces CYP3A4 and may reduce ivabradine efficacy.

Frequently Asked Questions

Ivabradin Stada is prescribed for chronic stable angina pectoris and for heart failure with reduced ejection fraction. In both cases the drug works by lowering the heart rate, which helps relieve angina symptoms and improves cardiac efficiency in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, the natural pacemaker of the heart. By inhibiting this inward sodium/potassium current, the spontaneous depolarisation of pacemaker cells slows, resulting in a reduced resting heart rate without affecting contractility.

The dosage of Ivabradin Stada is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate response, and any concomitant therapies. The prescriber will select the appropriate strength and titration schedule according to approved labeling.

Safety data for ivabradine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Ivabradin Stada product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting blood pressure or myocardial contractility. Beta‑blockers act on adrenergic receptors and have broader cardiovascular effects, which may be advantageous or limiting depending on the patient’s comorbidities.

Ivabradin Stada should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Ivabradin Stada is taken orally, usually with a glass of water. The tablet should be swallowed whole and not split, crushed, or chewed, unless the prescribing information specifically allows an alternative method.

The most serious risks include severe bradycardia, atrial fibrillation, and, rarely, symptomatic hypotension or visual disturbances that may affect daily activities. Patients should be monitored for these events, especially during dose initiation and titration.

Ivabradin Stada is contraindicated in patients with a resting heart rate below 50 bpm, those with acute decompensated heart failure, severe hepatic impairment, or known hypersensitivity to ivabradine or any excipients in the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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