Product image of Ivabradin Teva (Ivabradine) supplied by GNH India

Ivabradin Teva

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradin Teva (Ivabradine)

Ivabradine, the active ingredient in Ivabradin Teva, is a If channel inhibitor presented as an oral tablet for oral use. It reduces heart rate and is indicated for chronic stable angina pectoris and heart failure with reduced ejection fraction in suitable patients.

GNH India supplies Ivabradin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Clients benefit from comprehensive documentation, temperature‑controlled logistics where required, and responsive technical support.

Manufacturer / TM Owner

Teva Pharmaceuticals Cr, S.R.O.

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Indications & Clinical Uses

  • Ivabradine is used to manage conditions related to myocardial oxygen demand and heart‑rate regulation.
  • Chronic stable angina pectoris: improves exercise tolerance by lowering heart rate.
  • Heart failure with reduced ejection fraction: reduces hospitalization risk through heart‑rate reduction.
  • Patients intolerant to beta‑blockers: offers an alternative mechanism for heart‑rate control.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows spontaneous depolarization. By reducing this pacemaker current, the drug lowers resting heart rate without compromising myocardial contractility, thereby decreasing cardiac oxygen consumption and improving efficiency in ischemic and failing hearts.

Side Effects

Common Side Effects

  • Bradycardia: resting heart rate may fall below 50 bpm.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo: especially on standing.
  • Fatigue: general feeling of tiredness.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe bradycardia requiring medical intervention.
  • Atrial fibrillation or other significant arrhythmias.
  • Symptomatic hypotension leading to fainting.
  • Visual loss or persistent retinal changes.
  • Myocardial infarction in high‑risk patients.

Precautions & Warnings

  • Ivabradine should be prescribed only after confirming a resting heart rate above 50 bpm and evaluating for contraindications.
  • Monitor heart rate: ensure it remains within therapeutic range during therapy.
  • Assess for atrial fibrillation: discontinue if new‑onset AF occurs.
  • Avoid use in severe hepatic impairment: dose adjustment may be required.
  • Caution in patients with hypotension: monitor blood pressure regularly.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ivabradine may interact with drugs that affect cardiac conduction or metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may markedly increase plasma levels.
  • Concomitant use with other bradycardic agents (e.g., beta‑blockers, digoxin): risk of excessive heart‑rate reduction.
  • Certain anti‑arrhythmic drugs (e.g., amiodarone): can potentiate bradycardia.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may require dose adjustment.
  • Drugs that prolong QT interval: monitor ECG for additive effects.
  • Rifampicin (CYP3A4 inducer): may reduce ivabradine exposure, affecting efficacy.

Frequently Asked Questions

Ivabradin Teva contains ivabradine, which is prescribed for chronic stable angina pectoris and for heart failure with reduced ejection fraction. In both cases the drug helps lower heart rate, reducing myocardial oxygen demand and improving symptoms in patients who meet the clinical criteria.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, the heart’s natural pacemaker. By inhibiting this current, the drug slows the spontaneous depolarisation of pacemaker cells, leading to a lower resting heart rate without decreasing the strength of cardiac contraction.

The appropriate dose of Ivabradin Teva is determined by the prescribing clinician based on the patient’s heart‑rate, clinical condition, and any concomitant therapies. Dosage adjustments are made according to therapeutic response and tolerability, following local prescribing guidelines.

Safety data for ivabradine in pregnancy and lactation are limited, and the product is not classified for use in these populations. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled requirements), and necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on adrenergic receptors and can reduce contractility and blood pressure, making ivabradine a useful alternative when beta‑blockers are contraindicated or not tolerated.

Ivabradin Teva should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain potency throughout the shelf‑life.

The medication is taken orally, usually with a glass of water. It is typically administered twice daily, but the exact schedule and timing are set by the prescribing physician based on the individual’s clinical response and heart‑rate targets.

The most serious adverse events include severe bradycardia, atrial fibrillation, symptomatic hypotension, and rare visual disturbances that may affect retinal function. Patients should be monitored regularly for these events, and therapy should be discontinued if they occur.

Ivabradin Teva is contraindicated in patients with a resting heart rate below 50 bpm, those with acute decompensated heart failure, severe hypotension, sick sinus syndrome, or advanced atrioventricular block without a pacemaker. It should also be avoided in individuals with known hypersensitivity to ivabradine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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