Product image of Ivabradina Aurovitas (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Aurovitas

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Aurovitas (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Aurovitas, is a If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradina Aurovitas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurovitas Spain,s.A.U.

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Indications & Clinical Uses

Ivabradina Aurovitas acts on the cardiac If current to manage conditions where heart‑rate reduction is therapeutic.

  • Chronic stable angina: decreases frequency of angina attacks by lowering myocardial oxygen demand.
  • Heart failure with reduced ejection fraction: improves symptoms and reduces hospitalization risk through heart‑rate control.
  • Ischemic heart disease: alleviates chest pain by reducing cardiac workload.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows spontaneous depolarization. This reduction in pacemaker activity lowers heart rate without affecting myocardial contractility or blood pressure, providing symptom relief in angina and heart‑failure patients.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Bradycardia: heart rate below 50 bpm.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Nausea.

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical intervention.
  • Atrial fibrillation or other arrhythmias.
  • Severe hypotension.
  • Persistent visual impairment.
  • Hepatic dysfunction.
  • Allergic reactions including rash or angioedema.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors.

  • Cardiac monitoring: obtain baseline heart rate and ECG.
  • Concomitant beta‑blockers: assess for excessive bradycardia.
  • Severe hepatic impairment: use with caution or avoid.
  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • CYP3A4 inhibitors: monitor for increased exposure.
  • Store at below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Ivabradina Aurovitas may interact with several drug classes. Major Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise ivabradine levels.

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Other bradycardic agents (beta‑blockers, digoxin, amiodarone): risk of severe bradycardia.
  • Concomitant ivabradine with verapamil or diltiazem: can cause marked heart‑rate reduction.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers (verapamil, diltiazem): may modestly increase ivabradine exposure.
  • Antidepressants (fluoxetine, paroxetine): potential CYP3A4 inhibition.
  • Antihypertensives (ACE inhibitors, ARBs): monitor blood pressure and heart rate.
  • Diuretics: watch for electrolyte shifts that could affect cardiac conduction.

Frequently Asked Questions

Ivabradina Aurovitas is prescribed to lower heart rate in adults with chronic stable angina and in patients with heart failure that has a reduced ejection fraction. By reducing the heart’s pacing activity, it helps relieve chest pain and improves functional capacity in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. Inhibiting this current slows the spontaneous depolarisation of pacemaker cells, resulting in a lower heart rate without decreasing the strength of cardiac contraction or blood pressure.

The dose of Ivabradina Aurovitas is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate response, and tolerance. Dosage adjustments are made according to therapeutic goals and any concomitant medications, following local prescribing guidelines.

Safety data for ivabradine in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on adrenergic receptors and can reduce contractile force and blood pressure, which may be undesirable in some patients. Ivabradine is often considered when beta‑blockers are contraindicated or not tolerated.

Store Ivabradina Aurovitas at temperatures below 25 °C in its original container. Protect the tablets from moisture, direct sunlight and excessive heat to maintain stability and potency throughout the shelf‑life.

Ivabradina Aurovitas is taken orally, usually with a glass of water. The tablet should be swallowed whole and not split, crushed, or chewed, unless the prescribing information specifically allows it. Dosing times are generally spaced evenly to maintain consistent heart‑rate control.

The most serious adverse events include symptomatic bradycardia, atrial fibrillation, severe hypotension, persistent visual disturbances, and rare cases of hepatic dysfunction or severe allergic reactions. Patients should be monitored for these events, especially when initiating therapy or adjusting doses.

Ivabradina Aurovitas should be avoided in patients with severe hepatic impairment, uncontrolled hypotension, acute decompensated heart failure, or those with a resting heart rate below 50 bpm before treatment. It is also contraindicated in individuals taking strong CYP3A4 inhibitors without appropriate dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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