Product image of Ivabradina Ciclum (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Ciclum

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Ciclum (Ivabradine Hydrochloride)

Ivabradine Hydrochloride, the active ingredient in Ivabradina Ciclum, is a If channel inhibitor presented as an oral dosage form for oral use. It is indicated for chronic stable angina and heart failure with reduced ejection fraction in appropriate adult patients.

GNH India supplies Ivabradina Ciclum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

Ivabradina Ciclum, an If channel inhibitor, is used in cardiovascular conditions where heart rate reduction is beneficial.

  • Chronic stable angina: reduces the frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers heart rate, improving symptoms and decreasing hospitalization risk.

How It Works

  • Ivabradine Hydrochloride selectively inhibits the funny (If) current in the sino‑atrial node, which slows spontaneous depolarisation and reduces heart rate without altering myocardial contractility or ventricular repolarisation.

Side Effects

Ivabradina Ciclum may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache.
  • Dizziness.
  • Mild bradycardia.

Serious or Rare Side Effects

  • Severe bradycardia leading to syncope.
  • Atrial fibrillation.
  • Hepatic enzyme elevation.

Precautions & Warnings

When prescribing Ivabradina Ciclum, clinicians should observe the following precautions.

  • Monitor heart rate: obtain baseline and periodic measurements.
  • Avoid in severe hepatic impairment: dose adjustment not recommended.
  • Caution in sick sinus syndrome or AV block: contraindicated.
  • Use with other heart‑rate‑lowering agents cautiously: risk of excessive bradycardia.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Ivabradina Ciclum can interact with other medicines, requiring attention to avoid clinically significant effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine plasma levels.
  • Co‑administration with other If channel blockers (e.g., digoxin): risk of excessive heart‑rate reduction.
  • Concomitant use with potent CYP3A4 inducers (e.g., rifampicin): may markedly reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: additive bradycardic effect.
  • Calcium‑channel blockers (verapamil, diltiazem): increase ivabradine exposure.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): moderate CYP3A4 inhibition may raise drug levels.

Frequently Asked Questions

Ivabradina Ciclum contains ivabradine hydrochloride and is prescribed to lower heart rate in adults with chronic stable angina or heart failure with reduced ejection fraction, helping to relieve symptoms and reduce cardiovascular events.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, slowing the pacemaker activity of the heart. This reduces resting heart rate without affecting contractility, improving myocardial oxygen balance.

The appropriate dose of Ivabradina Ciclum is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate response, and tolerability. No fixed regimen is provided here.

Safety of ivabradine in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting contractility or blood pressure, whereas beta‑blockers act on adrenergic receptors and have broader cardiovascular effects.

Store at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and ensure the packaging remains tightly closed.

Ivabradina Ciclum is taken orally, usually as a tablet, with or without food, exactly as directed by the prescribing healthcare professional.

Serious risks include severe bradycardia that may cause syncope, atrial fibrillation, significant hepatic enzyme elevation, and rare visual disturbances that could affect vision.

Patients with sick sinus syndrome, second‑ or third‑degree atrioventricular block, severe hepatic impairment, or those taking strong CYP3A4 inhibitors should avoid ivabradine unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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