Product image of Ivabradina Fantex (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Fantex

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Fantex (Ivabradine Hydrochloride)

Ivabradine Hydrochloride, the active ingredient in Ivabradina Fantex, is an If channel inhibitor presented as an oral tablet for oral use. It is used to manage chronic heart failure and stable angina pectoris in adult patients by lowering heart rate without affecting contractility.

GNH India supplies Ivabradina Fantex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory‑compliant documentation for cross‑border procurement.

Manufacturer / TM Owner

Farmoz - Sociedade Técnico Medicinal, S.A.

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Indications & Clinical Uses

Ivabradina Fantex is indicated for conditions where reduction of heart rate improves clinical outcomes, primarily within the cardiovascular disease spectrum.

  • Chronic heart failure: improves symptoms, exercise tolerance and reduces hospitalization risk.
  • Stable angina pectoris: decreases frequency of angina attacks and improves exercise capacity.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node by binding to the HCN channel pore. This reduces spontaneous depolarisation, slowing pacemaker activity and lowering heart rate while myocardial contractility, ventricular repolarisation and blood pressure remain largely unchanged. The effect is dose‑dependent and reversible upon discontinuation.

Side Effects

Ivabradina Fantex may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Phosphenes (transient visual disturbances)
  • Bradycardia
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Symptomatic severe bradycardia
  • Atrial fibrillation
  • Marked hypotension
  • Allergic reactions (rash, angioedema)

Precautions & Warnings

When prescribing Ivabradina Fantex, clinicians should observe several safety measures.

  • Heart rate monitoring: check resting heart rate before initiation and periodically thereafter.
  • Contraindication in severe hypotension: avoid use in patients with systolic BP <90 mmHg.
  • Caution in hepatic impairment: dose adjustment may be required in moderate to severe liver disease.
  • Interaction with other bradycardic agents: use carefully when combined with beta‑blockers or digoxin.
  • Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Ivabradina Fantex can interact with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine exposure.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Concomitant use with other bradycardic agents (e.g., high‑dose beta‑blockers, digoxin): risk of excessive heart‑rate reduction.

Moderate Interactions (Monitor Closely)

  • Diltiazem and verapamil: may modestly increase ivabradine levels.
  • Amiodarone: potential additive effect on heart rate.
  • Antihypertensive drugs: may enhance blood‑pressure lowering.
  • Antidepressants metabolized by CYP3A4 (e.g., sertraline): monitor for increased exposure.

Frequently Asked Questions

Ivabradina Fantex contains ivabradine, which is prescribed to lower heart rate in adults with chronic heart failure or stable angina pectoris. By reducing the rate at which the heart beats, it helps relieve symptoms, improve exercise capacity, and decrease the risk of hospitalization associated with these cardiovascular conditions.

Ivabradine works by selectively blocking the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. This inhibition slows spontaneous electrical activity, leading to a lower heart rate while leaving myocardial contractility, blood pressure, and ventricular repolarisation largely unaffected.

The exact dose of Ivabradina Fantex is determined by the prescribing clinician based on the patient’s clinical status, heart‑rate targets, and tolerability. Physicians typically start with a low dose and adjust it according to therapeutic response and safety monitoring.

Safety data for ivabradine in pregnancy and lactation are limited. The product should be avoided unless the potential benefit to the mother clearly outweighs any possible risk to the fetus or infant. Women of child‑bearing potential should use effective contraception while on therapy.

To place an order, submit an enquiry on the Ivabradina Fantex product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but they act via different mechanisms. Beta‑blockers reduce heart rate by blocking adrenergic receptors and also lower blood pressure, whereas ivabradine selectively inhibits the If current without affecting contractility or blood pressure. Ivabradine may be added when beta‑blockers alone do not achieve target heart rates or are not tolerated.

Store Ivabradina Fantex at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Ivabradina Fantex is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s instructions regarding timing relative to meals to maintain consistent absorption.

The most serious adverse events include symptomatic severe bradycardia, atrial fibrillation or other arrhythmias, marked hypotension, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience fainting, rapid palpitations, severe dizziness, or signs of an allergic response.

Ivabradina Fantex is contraindicated in patients with severe hypotension (systolic BP <90 mmHg), acute decompensated heart failure, sick sinus syndrome, or those with a resting heart rate below 50 beats per minute. It should also be avoided in individuals taking strong CYP3A4 inhibitors without appropriate dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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