Product image of Ivabradina Generis (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Generis

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Generis (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Generis, is an If channel inhibitor presented as a tablet for oral use. It reduces heart rate in patients with chronic stable angina and heart failure with reduced ejection fraction.
GNH India supplies Ivabradina Generis as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

Ivabradina Generis acts on the cardiac If current to control heart rate in specific cardiovascular conditions.

  • Chronic stable angina pectoris: improves exercise tolerance and reduces the frequency of angina attacks.
  • Heart failure with reduced ejection fraction (NYHA II–III): lowers heart rate, helping to alleviate symptoms and improve functional capacity.
  • Coronary artery disease (as adjunct therapy): assists in heart‑rate control when beta‑blockers are unsuitable.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows spontaneous depolarisation. By reducing the slope of phase 4 depolarisation, the drug lowers heart rate without affecting myocardial contractility, ventricular repolarisation, or blood pressure, providing rate control in angina and heart‑failure patients.

Side Effects

Adverse reactions may occur with ivabradine therapy.

Common Side Effects

  • Bradycardia: excessively low heart rate.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Nausea.

Serious or Rare Side Effects

  • Symptomatic atrial fibrillation.
  • Severe hypotension.
  • Syncope (fainting).

Precautions & Warnings

Ivabradina Generis requires careful patient assessment and monitoring.

  • Cardiovascular assessment: evaluate baseline heart rate and rhythm before initiation.
  • Concomitant beta‑blocker use: avoid excessive heart‑rate reduction.
  • Liver impairment: dose adjustment may be needed.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Ivabradine may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase ivabradine plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): reduce ivabradine exposure.
  • Concomitant use with other bradycardic agents (e.g., digoxin, diltiazem): risk of severe bradycardia.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole): may modestly raise ivabradine concentrations.
  • Verapamil: can enhance bradycardic effect.
  • Antihypertensives: monitor blood pressure and heart rate.

Frequently Asked Questions

Ivabradina Generis is prescribed for chronic stable angina pectoris and for heart failure with reduced ejection fraction (NYHA class II–III). In both cases the drug helps control heart rate, reducing angina episodes and improving symptoms associated with heart failure.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, which is responsible for spontaneous pacemaker activity. By inhibiting this current, the drug slows the rate of depolarisation, leading to a lower heart rate without affecting the strength of cardiac contraction.

The dose of Ivabradina Generis is determined individually by the prescribing clinician based on the patient’s heart‑rate, clinical condition, and any concomitant therapies. The prescriber will set the appropriate strength and dosing schedule.

Safety of ivabradine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting contractility or blood pressure. Beta‑blockers act on adrenergic receptors and have broader cardiovascular effects, which may be contraindicated or less tolerated in some patients.

Store Ivabradina Generis at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ivabradina Generis is taken orally, usually with a glass of water. The exact timing (e.g., with or without food) and frequency are determined by the prescribing clinician based on the individual treatment plan.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and syncope. Patients should be monitored for signs of excessively low heart rate or arrhythmias, and therapy should be adjusted or discontinued if these events occur.

Ivabradina Generis should be avoided in patients with severe hepatic impairment, uncontrolled hypotension, acute decompensated heart failure, or those taking strong CYP3A4 inhibitors or other bradycardic agents that could cause excessive heart‑rate reduction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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