Product image of Ivabradina Kern Pharma (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Kern Pharma

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Kern Pharma (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Kern Pharma, is a If channel inhibitor presented as a tablet for oral use. It reduces heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradina Kern Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kern Pharma, S.L.

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Indications & Clinical Uses

  • Ivabradina Kern Pharma acts on the cardiac If current to manage conditions related to elevated heart rate.
  • Chronic stable angina: improves exercise tolerance by lowering heart rate without affecting contractility.
  • Heart failure with reduced ejection fraction: reduces hospitalization risk by maintaining a lower resting heart rate.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows depolarisation of pacemaker cells. This leads to a reduction in spontaneous heart rate while preserving myocardial contractility and blood pressure, providing symptomatic relief in angina and supporting ventricular function in heart failure.

Side Effects

Ivabradina Kern Pharma may cause a range of adverse reactions.

Common Side Effects

  • Visual disturbances (phosphenes)
  • Bradycardia
  • Headache
  • Dizziness
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Symptomatic hypotension
  • Severe bradyarrhythmias
  • Atrioventricular block
  • Acute coronary syndrome
  • Allergic skin reactions
  • Vision loss (rare)

Precautions & Warnings

  • Use of Ivabradina Kern Pharma requires careful clinical assessment.
  • Cardiac monitoring: baseline and periodic ECG to detect bradycardia.
  • Avoid in severe hepatic impairment: dose adjustment may be needed.
  • Concomitant beta‑blockers: monitor for excessive heart‑rate reduction.
  • Pregnancy and lactation: use only if benefits outweigh risks.
  • Drug interactions: review all concomitant medications.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Ivabradina Kern Pharma can interact with several medicines that affect heart rate or metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine exposure.
  • Concomitant ivabradine with other heart‑rate‑lowering agents (e.g., digoxin) in uncontrolled settings.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Verapamil or diltiazem: may modestly increase plasma levels.
  • Antihypertensives: monitor for additive blood‑pressure effects.

Frequently Asked Questions

Ivabradina Kern Pharma is prescribed for chronic stable angina and for heart failure with reduced ejection fraction. In both conditions it helps lower the heart rate, which can improve symptoms and reduce the risk of cardiovascular events when used as part of a comprehensive treatment plan.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, the heart’s natural pacemaker. By inhibiting this current, the drug slows the spontaneous depolarisation of pacemaker cells, resulting in a lower resting heart rate without decreasing the strength of cardiac contraction.

The specific dose of Ivabradina Kern Pharma is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate response, and tolerability. Dosage adjustments are made during treatment to achieve the target heart‑rate range while monitoring for side effects.

Safety data for ivabradine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivabradine lowers heart rate by targeting the If current, whereas beta‑blockers reduce heart rate through β‑adrenergic blockade. Ivabradine does not affect myocardial contractility or blood pressure, making it useful when beta‑blockers are contraindicated or insufficient, but it is often used in combination with beta‑blockers for additive effect.

Store Ivabradina Kern Pharma tablets at ambient temperature, preferably below 25 °C. Keep the product in its original packaging to protect it from moisture and light, and avoid storing it in areas with high humidity or extreme temperature fluctuations.

Ivabradina Kern Pharma is taken orally, usually with a glass of water. The tablets should be swallowed whole and not split, chewed, or crushed, unless the prescribing information specifically allows it. Dosing times are generally spaced evenly to maintain consistent blood levels.

Serious risks include symptomatic bradycardia, atrioventricular block, severe hypotension, and rare visual disturbances such as luminous phenomena or vision loss. Patients should be monitored for these events, especially during dose titration or when combined with other heart‑rate‑lowering agents.

Ivabradina Kern Pharma is contraindicated in patients with severe hepatic impairment, acute decompensated heart failure, sick sinus syndrome, or those with a resting heart rate below 50 beats per minute. It should also be avoided in individuals taking strong CYP3A4 inhibitors unless dosage adjustments are made under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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