Product image of Ivabradina Pensa (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Pensa

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Pensa (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Pensa, is a If channel inhibitor presented as an oral tablet for oral use. It reduces heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradina Pensa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant documentation for global distribution, following EU Good Manufacturing Practice to ensure batch consistency and safety.

Manufacturer / TM Owner

Towa Pharmaceutical S.A.

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Indications & Clinical Uses

Ivabradina Pensa acts on the cardiac If current to lower heart rate, providing therapeutic benefit in several cardiovascular conditions.

  • Chronic stable angina: reduces frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: decreases heart rate, contributing to better ventricular remodeling and reduced hospitalization risk.
  • Symptomatic tachycardia: lowers elevated heart rate when other rate‑controlling agents are unsuitable.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node by binding to the HCN channel pore. This reduces spontaneous depolarisation, slowing pacemaker activity and consequently lowering heart rate without affecting myocardial contractility or blood pressure. The effect is dose‑dependent, reversible upon discontinuation, and improves myocardial oxygen balance in angina and reduces cardiac workload in heart failure.

Side Effects

Ivabradina Pensa may be associated with several adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Bradycardia: heart rate below prescribed range.
  • Headache.
  • Dizziness.

Serious or Rare Side Effects

  • Symptomatic severe bradycardia requiring medical intervention.
  • Atrial fibrillation or other serious arrhythmias.
  • Persistent visual impairment or retinal toxicity.

Precautions & Warnings

When prescribing Ivabradina Pensa, clinicians should observe the following precautions to ensure patient safety.

  • Cardiovascular assessment: evaluate baseline heart rate and rhythm before initiation.
  • Monitor heart rate: check regularly, especially after dose changes.
  • Contraindication in severe hepatic impairment: avoid or use with caution.
  • Caution with sick sinus syndrome or atrioventricular block: may exacerbate bradyarrhythmias.
  • Drug interactions: avoid concomitant strong CYP3A4 inhibitors that can increase plasma levels.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture and light.

Avoid Interactions

Ivabradina Pensa can interact with other medicines, altering its plasma concentration or additive cardiac effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise ivabradine levels and increase bradycardia risk.
  • Other bradycardic agents (beta‑blockers, digoxin, diltiazem, verapamil): can cause excessive heart‑rate reduction.
  • Concomitant use with other If channel inhibitors: additive effect on heart rate.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole, erythromycin): may require dose adjustment.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): can lower ivabradine exposure, reducing efficacy.
  • Antihypertensive agents: monitor blood pressure and heart rate for additive effects.

Frequently Asked Questions

Ivabradina Pensa contains ivabradine, which is prescribed to lower heart rate in patients with chronic stable angina and in those with heart failure with reduced ejection fraction. By reducing the heart rate, it helps relieve angina symptoms and improves cardiac efficiency in heart failure.

Ivabradine works by selectively blocking the funny (If) current in the sinoatrial node. This inhibition slows the spontaneous electrical activity that sets the heart’s rhythm, leading to a reduction in heart rate without decreasing the strength of heart muscle contraction.

The dose of Ivabradina Pensa is individualized by the prescribing clinician based on the patient’s heart rate, clinical condition, and response to therapy. The prescriber determines the appropriate strength, frequency, and any necessary adjustments.

Safety data for ivabradine in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To request Ivabradina Pensa, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting blood pressure or myocardial contractility. Beta‑blockers act on adrenergic receptors and also reduce blood pressure, making ivabradine a useful alternative when beta‑blockers are contraindicated or not tolerated.

Store Ivabradina Pensa at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Ivabradina Pensa is taken orally, usually with a glass of water. The tablets should be swallowed whole and not crushed or chewed. Dosing times are typically spaced evenly, often twice daily, but the exact schedule is set by the prescribing healthcare professional.

The most serious risks include symptomatic severe bradycardia, which may require medical intervention, and the development of atrial fibrillation or other serious arrhythmias. Persistent visual disturbances, though rare, also warrant immediate medical attention.

Ivabradina Pensa should be avoided in patients with severe hepatic impairment, sick sinus syndrome, second‑ or third‑degree atrioventricular block, or in those taking strong CYP3A4 inhibitors that could raise drug levels. It is also contraindicated in individuals with known hypersensitivity to ivabradine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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