Product image of Ivabradina Stada (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Stada

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Stada (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Stada, is a If channel inhibitor presented as a tablet for oral use. It lowers heart rate by selective inhibition of the funny current in the sinoatrial node, and is used in chronic stable angina and heart failure with reduced ejection fraction.

GNH India supplies Ivabradina Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for importers global.

Manufacturer / TM Owner

Laboratorio Stada, S.L.

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Indications & Clinical Uses

Ivabradina Stada (ivabradine) is used in cardiovascular conditions where heart‑rate reduction is beneficial.

  • Chronic stable angina: reduces myocardial oxygen demand by lowering heart rate, improving exercise tolerance.
  • Heart failure with reduced ejection fraction: decreases heart rate, contributing to improved ventricular remodeling and reduced hospitalization risk.

How It Works

  • Ivabradine selectively blocks the funny (If) current in pacemaker cells of the sinoatrial node. By binding to the HCN channels responsible for the If current, it slows spontaneous depolarization, leading to a reduction in heart rate without affecting myocardial contractility, ventricular repolarisation, or blood pressure. This heart‑rate lowering effect improves the balance between myocardial oxygen supply and demand in patients with angina or heart failure.

Side Effects

Ivabradina Stada may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Bradycardia: heart rate lower than intended.
  • Headache.

Serious or Rare Side Effects

  • Atrial fibrillation.
  • Severe bradyarrhythmias.
  • Allergic reactions (rash, angioedema).

Precautions & Warnings

When prescribing Ivabradina Stada, clinicians should consider several precautionary measures to ensure safe use.

  • Dose titration: adjust gradually based on resting heart rate and clinical response.
  • Concomitant beta‑blockers: monitor for excessive bradycardia when combined.
  • CYP3A4 inhibitors: avoid strong inhibitors or reduce dose.
  • Visual symptoms: discontinue if persistent luminous phenomena occur.
  • Pregnancy and lactation: use only if benefits outweigh potential risks (category unknown).
  • Store at ambient temperature: keep below 25 °C, protect from moisture in original packaging.

Avoid Interactions

Ivabradina Stada can interact with other medicines, influencing heart rate or drug metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): may increase ivabradine exposure.
  • Concomitant use with other heart‑rate lowering agents (e.g., beta‑blockers, digoxin) leading to severe bradycardia.
  • AV‑node blocking drugs (e.g., verapamil, diltiazem): risk of excessive heart‑rate reduction.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole, erythromycin): may require dose adjustment.
  • Antihypertensives: monitor blood pressure and heart rate.
  • Diuretics in heart‑failure patients: watch for electrolyte shifts affecting cardiac conduction.

Frequently Asked Questions

Ivabradina Stada contains ivabradine, which is prescribed to lower heart rate in patients with chronic stable angina and in those with heart failure that has a reduced ejection fraction. By slowing the heart, it helps balance oxygen supply and demand in the myocardium.

Ivabradine works by selectively inhibiting the funny (If) current in the sinoatrial node. This action reduces the spontaneous firing rate of pacemaker cells, leading to a lower heart rate without affecting the strength of cardiac contraction or blood pressure.

The appropriate dose of Ivabradina Stada is determined by the prescribing physician based on the patient’s clinical condition, resting heart rate, and response to therapy. Dosage adjustments are made during follow‑up visits to achieve the target heart‑rate range.

Safety data for ivabradine during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

To request Ivabradina Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by targeting the If current without affecting contractility or blood pressure, whereas beta‑blockers act on adrenergic receptors and can reduce contractile force. Ivabradine is often added when beta‑blockers alone do not achieve the desired heart‑rate control.

Store Ivabradina Stada tablets at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the packaging.

Ivabradina Stada is taken orally as a tablet, usually with or without food. The tablet should be swallowed whole with a glass of water, and the dosing schedule set by the prescriber should be followed consistently each day.

The most serious adverse events include atrial fibrillation, severe bradyarrhythmias, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience palpitations, fainting, persistent visual disturbances, or signs of an allergic response.

Ivabradina Stada is contraindicated in patients with severe hypotension, sick sinus syndrome, second‑ or third‑degree atrioventricular block, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to ivabradine or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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