Product image of Ivabradina Tarbis Farma (Ivabradine) supplied by GNH India

Ivabradina Tarbis Farma

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradina Tarbis Farma (Ivabradine)

Ivabradine, the active ingredient in Ivabradina Tarbis Farma, is a If channel inhibitor presented as an oral formulation for oral use. It reduces heart rate by selectively inhibiting the funny current in the sino‑atrial node and is indicated for chronic heart failure and stable angina pectoris in adult patients.

GNH India supplies Ivabradina Tarbis Farma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

Ivabradine is used to manage conditions related to cardiac workload and heart rate.

  • Chronic heart failure with reduced ejection fraction: helps achieve target heart rate and may reduce hospitalization when added to guideline‑directed therapy.
  • Stable angina pectoris: relieves chest pain by lowering heart rate and myocardial oxygen demand.
  • Inadequate heart‑rate control despite beta‑blocker therapy: provides additional rate reduction without affecting contractility.

How It Works

  • Ivabradine selectively binds to the hyperpolarization‑activated cyclic nucleotide‑gated (HCN) channels that generate the funny (If) current in sino‑atrial node pacemaker cells. By inhibiting this inward Na⁺/K⁺ current, the drug slows diastolic depolarization, leading to a reduction in spontaneous firing rate of the SA node. The effect lowers heart rate without appreciable impact on myocardial contractility, ventricular repolarisation, or blood pressure.

Side Effects

Ivabradine may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Bradycardia: heart rate below prescribed range.
  • Headache: mild to moderate intensity.
  • Dizziness: may occur on standing.

Serious or Rare Side Effects

  • Atrial fibrillation: new onset arrhythmia.
  • Severe bradycardia requiring medical intervention.
  • Allergic reactions: rash, angioedema, or anaphylaxis.

Precautions & Warnings

When prescribing ivabradine, clinicians should consider several precautionary measures to ensure safe use.

  • Cardiac monitoring: assess heart rate and rhythm before and during therapy.
  • Concomitant beta‑blockers: avoid excessive bradycardia when combined.
  • Severe hepatic impairment: use with caution or avoid.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Visual disturbances: discontinue if persistent luminous phenomena occur.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Ivabradine can interact with other medicines, influencing its plasma levels or cardiac effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase ivabradine exposure, risk of bradycardia.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): reduce efficacy, may require dose adjustment.
  • Concomitant ivabradine with other heart‑rate lowering agents (beta‑blockers, digoxin) at high doses: risk of severe bradycardia.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may modestly raise ivabradine levels.
  • Antihypertensives: additive effect on blood pressure.
  • QT‑prolonging drugs: monitor cardiac rhythm.

Frequently Asked Questions

Ivabradina Tarbis Farma contains ivabradine, which is prescribed to lower heart rate in adults with chronic heart failure with reduced ejection fraction and in patients who experience stable angina pectoris. By reducing the heart rate, it helps lessen symptoms and may decrease the risk of hospitalization in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node by binding to HCN channels. This inhibition slows the spontaneous depolarisation of pacemaker cells, leading to a lower heart rate while preserving myocardial contractility and blood pressure.

The dose of ivabradine is individualized by the prescribing clinician based on the patient’s heart‑rate, clinical condition, and concomitant therapies. The prescriber determines the appropriate strength, frequency, and any necessary titration, following local labeling and guideline recommendations.

Safety data for ivabradine during pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Clinicians should discuss individual risk factors with the patient and consider alternative therapies when possible.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

The primary alternative for heart‑rate reduction in heart failure and angina is the beta‑blocker class. Unlike beta‑blockers, ivabradine lowers heart rate without affecting contractility or blood pressure, making it useful when beta‑blockers are contraindicated, not tolerated, or insufficient to achieve target heart rates.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use. Do not store in a refrigerator or freezer.

Ivabradina Tarbis Farma is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. Dosing times are typically spaced evenly (e.g., twice daily) as directed by the prescriber, and the medication should be taken with or without food according to label instructions.

The most serious adverse events include symptomatic bradycardia, atrial fibrillation, and severe allergic reactions such as rash, angioedema, or anaphylaxis. Patients should be instructed to report any new or worsening chest discomfort, fainting, palpitations, or visual disturbances promptly.

Ivabradine is contraindicated in patients with severe hepatic impairment, acute decompensated heart failure, sick sinus syndrome, or a resting heart rate below 50 bpm. It should also be avoided in individuals with known hypersensitivity to ivabradine or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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