Product image of Ivabradina Tecnigen (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Tecnigen

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Tecnigen (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Tecnigen, is a If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate without affecting myocardial contractility and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradina Tecnigen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable logistics and responsive technical support.

Manufacturer / TM Owner

Tecnimede España Ind. Fca., S.A.

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Indications & Clinical Uses

  • Ivabradine acts on the cardiac If current and is used in conditions where heart‑rate reduction improves symptoms.
  • Chronic stable angina: reduces frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers heart rate to improve ventricular filling and reduce hospitalizations.
  • Patients intolerant of beta‑blockers: provides heart‑rate control when beta‑blockers are contraindicated or not tolerated.

How It Works

  • Ivabradine selectively binds to the funny (If) channels in the sinoatrial node, inhibiting the inward mixed Na⁺/K⁺ current that drives spontaneous depolarisation. By reducing this pacemaker current, the drug slows the sinus rate without depressing myocardial contractility, ventricular repolarisation, or blood pressure, resulting in a controlled decrease in heart rate. The effect is dose‑dependent and reversible, allowing precise titration of heart rate in patients with angina or systolic dysfunction.

Side Effects

Ivabradine may be associated with several adverse reactions, which are grouped by frequency and clinical significance.

Common Side Effects

  • Luminous phenomena (phosphenes): transient visual sensations, especially in low light.
  • Bradycardia: resting heart rate below 50 bpm.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo: sensation of light‑headedness.

Serious or Rare Side Effects

  • Severe bradycardia with syncope: may require discontinuation.
  • Atrial fibrillation: new‑onset irregular rhythm.
  • Significant hypotension: symptomatic low blood pressure.
  • Elevated hepatic transaminases (rare): potential liver injury.

Precautions & Warnings

  • Before initiating ivabradine, several safety considerations should be evaluated.
  • Assess resting heart rate: ensure rate ≥ 70 bpm before starting.
  • Avoid in severe hepatic impairment: lack of safety data.
  • Monitor for symptomatic bradycardia: discontinue if heart rate falls below 50 bpm or patient experiences dizziness.
  • Caution with concomitant CYP3A4 inhibitors: may increase plasma concentrations.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Ivabradine interacts with several medicines that can alter its plasma level or additive heart‑rate effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause excessive bradycardia.
  • Co‑administration with other heart‑rate‑lowering agents (beta‑blockers, diltiazem, verapamil): risk of profound bradycardia.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (rifampicin, carbamazepine): may reduce efficacy.
  • Digitalis glycosides: may increase risk of bradycardia.
  • Antihypertensive agents: may enhance hypotensive effect.

Frequently Asked Questions

Ivabradina Tecnigen contains ivabradine, which is prescribed to lower heart rate in adults with chronic stable angina and in patients with heart failure with reduced ejection fraction. By reducing the heart rate, it helps relieve angina symptoms and improves cardiac efficiency in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the electrical pathway that initiates each heartbeat. Inhibiting this current slows the spontaneous depolarisation of pacemaker cells, producing a controlled reduction in heart rate without decreasing the strength of cardiac contraction.

The dose of ivabradine is individualized by the prescribing clinician based on the patient’s resting heart rate, clinical condition, and response to therapy. The prescriber determines the appropriate strength, frequency, and any necessary titration steps according to current medical guidelines.

Safety data for ivabradine during pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Ivabradina Tecnigen. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative for heart‑rate reduction in angina and heart failure is the beta‑blocker class. Unlike beta‑blockers, ivabradine lowers heart rate without affecting blood pressure or myocardial contractility, making it useful when beta‑blockers are contraindicated, not tolerated, or insufficient to achieve target heart rates.

Store the tablets at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in a refrigerator or freezer.

Ivabradina Tecnigen is taken orally as a whole tablet with a glass of water. It may be taken with or without food, but the same conditions should be maintained for each dose. Patients should follow the dosing schedule prescribed by their clinician and not split or crush the tablet.

The most serious adverse events include severe bradycardia that can lead to syncope, new‑onset atrial fibrillation, significant hypotension, and rare cases of liver enzyme elevation. Patients should seek immediate medical attention if they experience fainting, rapid irregular heartbeat, severe dizziness, or signs of liver dysfunction.

Ivabradine is contraindicated in patients with a resting heart rate below 50 bpm, those with sick sinus syndrome, second‑ or third‑degree atrioventricular block (unless a pacemaker is present), severe hepatic impairment, and in individuals taking strong CYP3A4 inhibitors without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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