Product image of Ivabradina Teva (Ivabradine) supplied by GNH India

Ivabradina Teva

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradina Teva (Ivabradine)

Ivabradine, the active ingredient in Ivabradina Teva, is an If channel inhibitor presented as a tablet for oral use. It lowers heart rate without affecting contractility and is used to manage chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradina Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from comprehensive regulatory support and transparent pricing.

Manufacturer / TM Owner

Teva Pharma – Produtos Farmacêuticos Lda

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Indications & Clinical Uses

Ivabradine is an If channel inhibitor used in cardiovascular conditions to control heart rate.

  • Chronic stable angina pectoris: reduces frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction: improves symptoms and reduces hospitalizations through heart rate reduction.
  • Elevated resting heart rate: provides selective heart rate lowering without affecting myocardial contractility.

How It Works

  • Ivabradine selectively blocks the funny (If) current in the sinoatrial node, which is responsible for spontaneous pacemaker activity. By inhibiting this inward sodium/potassium current, the drug slows diastolic depolarisation, leading to a reduction in heart rate while preserving myocardial contractile force and ventricular conduction.

Side Effects

Ivabradine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Visual disturbances (phosphenes)
  • Bradycardia
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Symptomatic bradycardia
  • Atrial fibrillation
  • Severe hypotension
  • Visual loss

Precautions & Warnings

Before prescribing ivabradine, clinicians should consider several safety measures.

  • Baseline heart rate assessment: measure resting heart rate before initiating therapy.
  • Concomitant beta‑blocker use: monitor for excessive bradycardia when combined.
  • Severe hepatic impairment: avoid or use with caution.
  • Pregnancy: risk unknown; prescribe only if benefits outweigh risks.
  • Breastfeeding: not recommended due to insufficient data.
  • Store at below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Ivabradine interacts with several drug classes that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine levels.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Other bradycardic agents (beta‑blockers, digoxin, diltiazem): risk of severe bradycardia.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., verapamil, diltiazem): may modestly raise plasma concentrations.
  • Antidepressants (e.g., fluoxetine, paroxetine): potential increase in exposure.
  • Diuretics: monitor electrolytes and blood pressure.

Frequently Asked Questions

Ivabradina Teva contains ivabradine, which is prescribed to lower heart rate in adults with chronic stable angina pectoris and in patients with heart failure with reduced ejection fraction. By reducing heart rate, it helps relieve angina symptoms and improves functional capacity in heart‑failure patients.

Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, the electrical signal that initiates each heartbeat. Blocking this current slows the pacemaker activity, resulting in a lower heart rate while leaving contractility and blood pressure largely unchanged.

The dose of ivabradine is individualized by the prescribing clinician based on the patient’s resting heart rate, clinical condition, and response to therapy. The prescriber determines the appropriate strength, frequency, and any necessary titration.

The safety of ivabradine during pregnancy and lactation has not been established. It is classified as having an unknown pregnancy category, and use is generally avoided unless the potential benefit justifies the potential risk to the fetus. Breastfeeding is not recommended because the drug may pass into milk.

To request Ivabradina Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by directly inhibiting the If current without affecting beta‑adrenergic receptors. This means it does not influence blood pressure or contractility, making it useful when beta‑blockers are contraindicated or insufficient. However, beta‑blockers also provide anti‑arrhythmic and anti‑ischemic benefits that ivabradine lacks.

Ivabradina Teva tablets should be stored at temperatures below 25 °C, in their original container, and protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

The medication is taken orally as a whole tablet, with or without food, according to the prescriber’s instructions. Patients should swallow the tablet with water and avoid crushing or chewing it, as this could affect the drug’s release profile.

The most concerning adverse events include symptomatic bradycardia, atrial fibrillation, severe hypotension, and visual loss (including luminous phenomena). Patients should be monitored for these events, especially when combined with other heart‑rate‑lowering agents or in those with pre‑existing conduction disorders.

Ivabradine is contraindicated in patients with severe sinus bradycardia (resting heart rate <50 bpm), sick sinus syndrome, second‑ or third‑degree atrioventricular block, acute decompensated heart failure, and in those taking strong CYP3A4 inhibitors that could raise drug levels. It should also be avoided in individuals with known hypersensitivity to ivabradine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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