Product image of Ivabradina Teva Group (Ivabradine) supplied by GNH India

Ivabradina Teva Group

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradina Teva Group (Ivabradine)

Ivabradine, the active ingredient in Ivabradina Teva Group, is an If channel inhibitor presented as an oral tablet for systemic use. It selectively lowers heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.

GNH India supplies Ivabradina Teva Group as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets EU quality standards, is manufactured under GMP conditions, and our distribution network ensures timely delivery across multiple continents.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Ivabradine is used in cardiovascular conditions that involve elevated heart rate.

  • Chronic stable angina: reduces the frequency of angina attacks by lowering myocardial oxygen demand.
  • Heart failure with reduced ejection fraction: improves symptoms and may decrease hospitalisation rates.
  • Ischemic heart disease (coronary artery disease): helps control heart rate to lessen myocardial workload.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows spontaneous depolarisation and reduces heart rate. The drug does not affect myocardial contractility, ventricular repolarisation, or blood pressure, allowing a heart‑rate‑centric approach to managing angina and heart‑failure symptoms.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Phosphenes (luminous visual phenomena)
  • Bradycardia (slow heart rate)
  • Headache
  • Dizziness
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Severe bradycardia leading to syncope
  • Atrioventricular block
  • Worsening heart failure
  • Visual impairment (persistent disturbances)
  • Angioedema

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Heart‑rate monitoring: check resting heart rate and discontinue if it falls below 50 bpm.
  • Hepatic impairment: use with caution in patients with moderate to severe liver disease.
  • Concomitant bradycardic agents: avoid combining with beta‑blockers or digoxin without close supervision.
  • Sick‑sinus syndrome or AV‑block: contraindicated in patients with these rhythm disorders.
  • Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ivabradine may interact with several medicines that affect heart rate or its metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine exposure.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Other bradycardic agents (beta‑blockers, digoxin, verapamil): risk of excessive heart‑rate reduction.

Moderate Interactions (Monitor Closely)

  • Verapamil or diltiazem: may modestly raise ivabradine levels.
  • Quinidine: can increase plasma concentrations.
  • Amiodarone: may enhance bradycardic effect, requiring heart‑rate monitoring.

Frequently Asked Questions

Ivabradina Teva Group contains ivabradine, which is prescribed for chronic stable angina and for heart failure with reduced ejection fraction. In both cases the drug works by lowering heart rate, helping to reduce chest pain episodes and improve heart‑failure symptoms.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. By inhibiting this current, the drug slows the spontaneous firing of the node, reducing heart rate without affecting contractility, which lessens myocardial oxygen demand.

The exact dose and dosing schedule are determined by the prescribing clinician based on the patient’s clinical status, heart‑rate response, and tolerance. Ivabradina Teva Group is supplied as a prescription‑only oral tablet, and dosing should follow the prescriber’s instructions.

Safety data for ivabradine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but they act via different mechanisms. Ivabradine selectively inhibits the If current without affecting blood pressure or contractility, whereas beta‑blockers block adrenergic receptors and can also reduce blood pressure. Ivabradine may be chosen when beta‑blockers are contraindicated or not tolerated.

Store the tablets at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, heat and direct sunlight to maintain product stability throughout its shelf life.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not crushed or chewed, unless the prescribing information specifically allows it.

Serious risks include severe bradycardia, atrioventricular block, syncope, and worsening heart failure. Patients should be monitored for symptoms such as dizziness, fainting, or palpitations, and the drug should be discontinued if heart rate falls below the safe threshold.

Ivabradina Teva Group is contraindicated in patients with sick‑sinus syndrome, second‑ or third‑degree atrioventricular block, severe hepatic impairment, or those who are already on strong CYP3A4 inhibitors without appropriate dose adjustment. It should also be avoided in individuals with known hypersensitivity to ivabradine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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