Product image of Ivabradina Teva Italia (Ivabradine) supplied by GNH India

Ivabradina Teva Italia

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradina Teva Italia (Ivabradine)

Ivabradine, the active ingredient in Ivabradina Teva Italia, is an If channel inhibitor presented as an oral tablet for oral use. It is indicated for chronic stable angina and for heart failure with reduced ejection fraction, helping to lower heart rate without affecting contractility in adult patients.

GNH India supplies Ivabradina Teva Italia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for import and distribution.

Manufacturer / TM Owner

Teva Italia S.R.L.

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Indications & Clinical Uses

Ivabradine is an If channel inhibitor used in cardiovascular conditions where heart rate reduction is beneficial.

  • Chronic stable angina: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction: improves symptoms and may reduce hospitalisation by decreasing heart rate.
  • Patients intolerant to beta‑blockers: offers an alternative mechanism to achieve heart‑rate control.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, decreasing the slope of diastolic depolarisation. This action slows pacemaker activity, resulting in a reduced heart rate while preserving myocardial contractility and without significant effects on blood pressure or ventricular repolarisation.

Side Effects

Ivabradine may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Bradycardia: excessively low heart rate.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache.
  • Dizziness.

Serious or Rare Side Effects

  • Severe bradyarrhythmia: symptomatic sinus pause.
  • Atrial fibrillation: new onset arrhythmia.
  • Marked hypotension: significant drop in blood pressure.

Precautions & Warnings

When prescribing Ivabradine, several safety considerations should be observed.

  • Dose adjustment: required in patients with hepatic impairment.
  • Monitoring: regular ECG and heart‑rate assessment recommended.
  • Contraindication: not for patients with acute decompensated heart failure or severe hypotension.
  • Caution: avoid use with strong CYP3A4 inhibitors.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Ivabradine can interact with other medicines, necessitating careful review of a patient’s regimen.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine plasma levels.
  • Concomitant use with other bradycardic agents (e.g., beta‑blockers, digoxin): risk of excessive heart‑rate reduction.
  • Verapamil or diltiazem: potentiate ivabradine effect on heart rate.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole): may require dose adjustment.
  • Drugs affecting QT interval (e.g., certain antiarrhythmics): monitor ECG for prolongation.

Frequently Asked Questions

Ivabradina Teva Italia contains ivabradine, which is prescribed to lower heart rate in adults with chronic stable angina and in patients with heart failure with reduced ejection fraction. By reducing the heart rate, it helps relieve angina symptoms and improves functional capacity in heart‑failure patients.

Ivabradine works by selectively blocking the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. This reduces the slope of diastolic depolarisation, slowing the heart’s intrinsic pacing and lowering heart rate without diminishing myocardial contractility or blood pressure.

The dosage of Ivabradina Teva Italia is determined by the prescribing clinician based on the individual’s clinical condition, heart‑rate response, and tolerability. The prescriber will set the appropriate dose and titration schedule according to current therapeutic guidelines.

Safety of ivabradine during pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

The primary alternative for heart‑rate control in angina and heart failure is the beta‑blocker class. Unlike beta‑blockers, ivabradine lowers heart rate without affecting beta‑adrenergic receptors, which can be advantageous in patients who cannot tolerate beta‑blockers due to bronchospasm, severe asthma, or peripheral vascular disease.

Ivabradina Teva Italia should be stored at ambient temperature below 25 °C. Keep the tablets in the original blister pack, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

The medication is administered orally, usually as a tablet taken with or without food. The exact timing and frequency are prescribed by the treating physician, who will also advise on any necessary adjustments based on heart‑rate monitoring.

Serious risks include severe bradycardia, symptomatic sinus pauses, atrial fibrillation, and marked hypotension. Patients should be educated to report symptoms such as dizziness, fainting, palpitations, or visual disturbances promptly to their healthcare provider.

Ivabradina Teva Italia is contraindicated in patients with acute decompensated heart failure, severe hypotension, sick sinus syndrome, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to ivabradine or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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