Product image of Ivabradina Tolife (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Tolife

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Tolife (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Tolife, is an If channel inhibitor presented as an oral tablet for oral use. It is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.
GNH India supplies Ivabradina Tolife as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Towa Pharmaceutical S.A.

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Indications & Clinical Uses

  • Ivabradina Tolife is used in cardiovascular conditions that benefit from heart‑rate reduction without affecting contractility.
  • Chronic stable angina: improves exercise tolerance and reduces angina episodes.
  • Heart failure with reduced ejection fraction: lowers heart rate to improve ventricular filling and symptoms.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which controls spontaneous depolarisation. By reducing this pacemaker current, the drug slows the heart rate while preserving myocardial contractility and blood pressure, helping to decrease myocardial oxygen demand in angina and improve haemodynamic efficiency in heart failure.

Side Effects

Ivabradina Tolife may be associated with several adverse reactions.

Common Side Effects

  • Bradycardia: heart rate slower than expected.
  • Visual disturbances: transient luminous phenomena (phosphenes).
  • Headache.
  • Dizziness or light‑headedness.
  • Fatigue.
  • Blurred vision.

Serious or Rare Side Effects

  • Symptomatic hypotension.
  • Atrial fibrillation.
  • Severe bradyarrhythmias requiring medical attention.
  • Allergic skin reactions.
  • Hepatic enzyme elevations.
  • Cardiac arrest (extremely rare).

Precautions & Warnings

  • When prescribing Ivabradina Tolife, clinicians should consider several safety measures.
  • Heart‑rate monitoring: ensure resting heart rate remains above 50 bpm before initiation.
  • Severe hepatic impairment: use with caution or avoid.
  • Hypotension: assess blood pressure regularly.
  • Concurrent bradycardic agents: avoid combining with beta‑blockers or digoxin without supervision.
  • Pregnancy and lactation: evaluate risk‑benefit, as safety data are limited.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Ivabradina Tolife can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ivabradine levels.
  • Other heart‑rate‑lowering drugs (beta‑blockers, digoxin): risk of excessive bradycardia.
  • Certain antiarrhythmic agents (e.g., amiodarone): can potentiate bradycardic effects.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole): may modestly raise plasma concentrations.
  • Antihypertensive agents (ACE inhibitors, diuretics): monitor blood pressure.
  • Drugs affecting hepatic metabolism (e.g., rifampicin): may reduce efficacy.
  • Herbal supplements containing St. John’s wort: possible induction of metabolism.
  • Concomitant use with other anti‑anginal agents: assess overall heart‑rate control.

Frequently Asked Questions

Ivabradina Tolife is prescribed for chronic stable angina and for heart failure with reduced ejection fraction. In both conditions it helps lower the heart rate, which reduces myocardial oxygen demand and can improve symptoms such as chest pain and exercise intolerance.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. By inhibiting this current, the drug slows spontaneous depolarisation, reducing the heart rate without diminishing the strength of cardiac contraction.

The exact dose of Ivabradina Tolife is determined by the prescribing clinician based on the patient’s clinical status, heart‑rate targets, and any concomitant therapies. Dosage adjustments are made according to therapeutic response and tolerability.

Safety data for ivabradine in pregnancy and lactation are limited. Prescribers should weigh potential benefits against possible risks and consider alternative therapies when safer options are available. Consultation with a specialist is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so without affecting myocardial contractility or blood pressure, making it useful when beta‑blockers are contraindicated or not tolerated. Beta‑blockers also provide additional anti‑adrenergic effects, so the choice depends on individual patient factors.

Ivabradina Tolife should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ivabradina Tolife is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. Administration timing (e.g., with meals) follows the prescriber’s instructions to maintain consistent plasma levels.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and rare cases of visual disturbances such as persistent phosphenes. Patients should be monitored for these events, especially during dose initiation and when combined with other heart‑rate‑lowering drugs.

Ivabradina Tolife is contraindicated in patients with severe hepatic impairment, acute decompensated heart failure, sick sinus syndrome, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with a resting heart rate below 50 bpm unless closely supervised.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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