Product image of Ivabradina Vir (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Vir

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Vir (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Vir, is an If channel inhibitor presented as an oral tablet for oral use. It reduces heart rate and is employed in chronic stable angina and heart failure in appropriate patients.

GNH India supplies Ivabradina Vir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Industria Química Y Farmaceútica Vir, S.A.

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Indications & Clinical Uses

Ivabradina Vir (ivabradine) is used in cardiovascular conditions that involve elevated heart rate.

  • Chronic stable angina: lowers heart rate to reduce frequency of angina episodes.
  • Heart failure (NYHA class II‑III): improves symptoms and may decrease hospitalisation by controlling heart rate.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows the pacemaker activity of the heart. This reduction in automaticity lowers heart rate without affecting myocardial contractility or blood pressure, providing rate control in patients with angina or heart failure.

Side Effects

Ivabradina Vir may cause a range of adverse reactions, which are categorised by frequency and severity.

Common Side Effects

  • Bradycardia: resting heart rate may fall below 50 bpm.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache: mild to moderate intensity.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Symptomatic bradycardia: may cause syncope or fatigue.
  • Atrial fibrillation: irregular heart rhythm requiring medical attention.
  • Severe visual impairment: persistent blurred vision or colour disturbances.
  • Hepatic enzyme elevation: significant increase in liver transaminases.

Precautions & Warnings

Before prescribing Ivabradina Vir, clinicians should observe the following precautions.

  • Baseline heart rate assessment: ensure resting HR ≥ 50 bpm before initiation.
  • Acute decompensated heart failure: avoid use in patients with worsening symptoms.
  • Concomitant CYP3A4 inhibitors: use caution as they can raise ivabradine plasma levels.
  • Monitoring for bradycardia: regularly check pulse and symptoms of dizziness.
  • Visual disturbances: discontinue if persistent or severe visual symptoms occur.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ivabradina Vir interacts with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): markedly increase ivabradine exposure.
  • Co‑administration with other heart‑rate‑lowering agents (beta‑blockers, digoxin): risk of excessive bradycardia.
  • Verapamil: potent CYP3A4 inhibition leading to elevated drug levels.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., diltiazem, fluconazole): may require dose adjustment.
  • QT‑prolonging drugs (e.g., certain antiarrhythmics): increase risk of cardiac arrhythmias.
  • Smoking: induces CYP3A4 and can reduce ivabradine effectiveness.

Frequently Asked Questions

Ivabradina Vir contains ivabradine, which is prescribed to lower heart rate in patients with chronic stable angina and in those with heart failure classified as NYHA class II or III. By reducing the heart rate, it helps relieve angina symptoms and improves functional capacity in heart‑failure patients.

Ivabradine works by selectively blocking the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. This inhibition slows the spontaneous depolarisation of pacemaker cells, leading to a lower heart rate while preserving myocardial contractility and blood pressure.

The dose of Ivabradina Vir is individualized by the prescribing clinician based on the patient’s resting heart rate, clinical condition, and response to therapy. The prescriber determines the appropriate strength, frequency and any necessary titration.

The safety of ivabradine in pregnancy and lactation has not been established. It is classified as having an unknown pregnancy category, and the drug should only be used if the potential benefit justifies the potential risk to the fetus or infant.

To order Ivabradina Vir, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by inhibiting the If current without affecting beta‑adrenergic receptors. This means it does not influence blood pressure or contractility, making it useful for patients who cannot tolerate beta‑blockers or need additional rate control.

Ivabradina Vir should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Ivabradina Vir is taken orally, usually with a glass of water. The tablet should be swallowed whole and not split, crushed or chewed, unless the prescribing information specifically allows an alternative method.

The most serious risks include symptomatic bradycardia that can lead to dizziness or syncope, atrial fibrillation, and severe visual disturbances such as persistent blurred vision. Patients should be instructed to report any of these symptoms promptly.

Ivabradina Vir should not be used in patients with a resting heart rate below 50 bpm, those with acute decompensated heart failure, severe hepatic impairment, or in individuals taking strong CYP3A4 inhibitors without appropriate dose adjustment. Contra‑indications are detailed in the prescribing information.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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