Product image of Ivabradín Teva Slovakia (Ivabradine) supplied by GNH India

Ivabradín Teva Slovakia

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradín Teva Slovakia (Ivabradine)

Ivabradine, the active ingredient in Ivabradín Teva Slovakia, is an If channel inhibitor presented as an oral dosage form for oral use. It is used to lower heart rate in patients with chronic stable angina pectoris and in heart failure with reduced ejection fraction.

GNH India supplies Ivabradín Teva Slovakia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharmaceuticals Slovakia S.R.O

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Indications & Clinical Uses

  • Ivabradine is used to manage cardiac conditions that benefit from selective heart‑rate reduction.
  • Chronic stable angina pectoris: reduces the frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers resting heart rate, helping to alleviate symptoms and decrease hospitalization risk.
  • Elevated resting heart rate in coronary artery disease: helps control heart rate when beta‑blockers are not tolerated.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which is responsible for spontaneous depolarisation. By blocking this pacemaker current, the drug slows the rate of depolarisation, resulting in a reduction of heart rate without affecting myocardial contractility or blood pressure.

Side Effects

Adverse reactions may occur with ivabradine therapy.

Common Side Effects

  • Visual disturbances (phosphenes)
  • Headache
  • Dizziness
  • Fatigue
  • Nausea

Serious or Rare Side Effects

  • Severe bradycardia
  • Atrial fibrillation
  • Symptomatic hypotension
  • Visual loss
  • Elevated liver enzymes

Precautions & Warnings

  • Use ivabradine with careful clinical monitoring.
  • Monitor heart rate: ensure resting heart rate remains above the recommended minimum.
  • Avoid in severe hepatic impairment: reduced metabolism may increase exposure.
  • Caution with sick‑sinus syndrome: risk of excessive bradycardia.
  • Do not combine with other strong heart‑rate‑lowering agents without supervision.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradine may interact with several medicines.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
  • Concomitant use with other heart‑rate‑lowering drugs (beta‑blockers, digoxin)
  • Calcium‑channel blockers that inhibit CYP3A4 (verapamil, diltiazem)

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (fluconazole, erythromycin)
  • CYP3A4 inducers (rifampicin, carbamazepine) may reduce efficacy
  • Antacids or agents that alter gastric pH may affect absorption

Frequently Asked Questions

Ivabradín Teva Slovakia contains ivabradine, which is prescribed to lower heart rate in patients with chronic stable angina pectoris and in those with heart failure with reduced ejection fraction. It may also be considered when controlling an elevated resting heart rate in coronary artery disease.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. By inhibiting this current, the drug slows the spontaneous depolarisation of pacemaker cells, reducing the heart rate without affecting the strength of cardiac contraction.

The specific dose of Ivabradín Teva Slovakia is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate response, and tolerance. Dosage adjustments are made according to individual therapeutic goals and safety monitoring.

The safety of ivabradine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on adrenergic receptors and have broader cardiovascular effects, which may be advantageous or limiting depending on the patient’s profile.

Ivabradín Teva Slovakia should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Do not store in a bathroom or near heat sources, and keep the container tightly closed when not in use.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless otherwise instructed.

The most serious risks include severe bradycardia, atrial fibrillation, symptomatic hypotension, and rare visual disturbances that may affect vision. Patients should be monitored for these events, especially during dose initiation and titration.

Ivabradine is contraindicated in patients with acute decompensated heart failure, severe hypotension, sick‑sinus syndrome, sinoatrial block, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to ivabradine or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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