Product image of Ivabradine Ab (Ivabradine) supplied by GNH India

Ivabradine Ab

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradine Ab (Ivabradine)

Ivabradine, the active ingredient in Ivabradine Ab, is a If channel inhibitor presented as an oral tablet for oral use. It treats chronic stable angina pectoris and heart failure with reduced ejection fraction in appropriate patients, helping to lower heart rate without affecting contractility.

GNH India supplies Ivabradine Ab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

  • Ivabradine is used in cardiovascular conditions where heart‑rate reduction improves outcomes.
  • Chronic stable angina pectoris: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction (NYHA class II–III): improves exercise capacity and lowers risk of hospitalization.
  • Stable coronary artery disease: helps control heart rate to relieve ischemic symptoms.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows the spontaneous depolarisation of pacemaker cells. By reducing the slope of phase 4 depolarisation, the drug lowers heart rate without altering myocardial contractility, ventricular repolarisation, or blood pressure, providing a targeted anti‑anginal and heart‑failure effect.

Side Effects

Ivabradine may cause a range of adverse reactions, most of which are related to its heart‑rate‑lowering action or visual perception.

Common Side Effects

  • Bradycardia: heart rate falls below the intended range.
  • Phosphenes (visual luminous phenomena): transient bright spots in vision.
  • Headache: mild to moderate discomfort.
  • Dizziness or light‑headedness.
  • Fatigue or general weakness.
  • Blurred vision.

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical attention.
  • Atrial fibrillation or other arrhythmias.
  • Severe hypotension with syncope.
  • Symptomatic heart block.
  • Persistent visual impairment.
  • Allergic reactions such as rash or angioedema.

Precautions & Warnings

  • Before prescribing ivabradine, clinicians should consider several safety measures.
  • Cardiovascular assessment: confirm resting heart rate and sinus rhythm.
  • Concomitant beta‑blocker use: monitor for excessive bradycardia when combined.
  • CYP3A4 inhibitors: avoid strong inhibitors or adjust therapy.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Renal or hepatic impairment: evaluate need for dose modification.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Ivabradine interacts with several medicines that affect heart rate or its metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause toxic levels.
  • Other heart‑rate‑lowering agents (beta‑blockers, diltiazem, verapamil): risk of severe bradycardia.
  • Pacemaker dependence: may interfere with device function.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole): monitor heart rate.
  • Digoxin: observe for additive effects on cardiac conduction.
  • Antihypertensives: watch for excessive blood‑pressure reduction.
  • Diuretics: assess electrolyte balance and volume status.

Frequently Asked Questions

Ivabradine Ab is indicated for chronic stable angina pectoris and for heart failure with reduced ejection fraction in patients classified as NYHA class II or III. In both conditions the drug works by lowering heart rate, which helps relieve chest pain and improves functional capacity.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, the pacemaker of the heart. By inhibiting this current, the drug slows the spontaneous depolarisation of pacemaker cells, resulting in a reduced heart rate without affecting the strength of cardiac contraction.

The specific dose of Ivabradine Ab is determined by the prescribing clinician based on the patient’s heart rate, clinical condition, and concomitant therapies. Dosage adjustments may be required for renal or hepatic impairment, and the prescriber will provide individualized instructions.

The safety of ivabradine in pregnancy and lactation has not been established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so without affecting myocardial contractility or blood pressure, making it useful when beta‑blockers are contraindicated or insufficient. Beta‑blockers also reduce contractility and have broader autonomic effects, which may be advantageous or limiting depending on the patient.

Ivabradine Ab should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Ivabradine Ab is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not crushed or chewed, to ensure consistent absorption and therapeutic effect.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and heart block. Patients should be monitored for signs of excessively low heart rate, dizziness, fainting, or new arrhythmias, and medical attention should be sought promptly if these occur.

Ivabradine should not be used in patients with acute decompensated heart failure, severe hypotension, sick sinus syndrome, or those with a resting heart rate below 60 bpm unless a pacemaker is in place. It is also contraindicated in individuals taking strong CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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