Product image of Ivabradine Accord (Ivabradine Hydrochloride) supplied by GNH India

Ivabradine Accord

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradine Accord (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradine Accord, is a If channel inhibitor presented as a tablet for oral use. It lowers heart rate to treat chronic stable angina pectoris and heart failure with reduced ejection fraction in adult patients.
GNH India supplies Ivabradine Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Ivabradine acts on the cardiac sinus node to reduce heart rate, benefiting conditions where heart‑rate control improves outcomes.

  • Chronic stable angina pectoris: decreases the frequency of angina attacks by lowering myocardial oxygen demand.
  • Heart failure with reduced ejection fraction: improves exercise capacity and reduces hospitalization by maintaining a lower resting heart rate.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows the spontaneous depolarisation of pacemaker cells. This reduction in automaticity lowers heart rate without affecting myocardial contractility or systemic blood pressure, providing symptom relief in angina and improving haemodynamic efficiency in heart failure.

Side Effects

Ivabradine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Bradycardia: resting heart rate below the intended target.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Blurred vision.

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical intervention.
  • Atrial fibrillation or other arrhythmias.
  • Severe visual impairment.
  • Hypotension not related to other agents.
  • Allergic skin reactions.
  • Hepatic enzyme elevations.

Precautions & Warnings

Before prescribing Ivabradine, clinicians should assess several safety factors.

  • Monitor heart rate: confirm resting HR > 50 bpm prior to initiation and during therapy.
  • Avoid in severe hepatic impairment: reduced metabolism may increase exposure.
  • Caution with concomitant CYP3A4 inhibitors: may raise plasma levels.
  • Discontinue if symptomatic bradycardia or atrial fibrillation occurs.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Ivabradine can interact with drugs that affect heart rate or its metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): markedly increase Ivabradine concentrations.
  • Other bradycardic agents (beta‑blockers, digoxin): risk of excessive heart‑rate reduction.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (diltiazem, verapamil): may require dose adjustment.
  • CYP3A4 inducers (rifampicin, carbamazepine): can lower efficacy.
  • Drugs that prolong QT interval: additive risk of arrhythmia.

Frequently Asked Questions

Ivabradine Accord is prescribed to manage chronic stable angina pectoris and to improve outcomes in patients with heart failure with reduced ejection fraction by selectively lowering heart rate without affecting blood pressure or contractility.

Ivabradine blocks the funny (If) current in the sino‑atrial node, which slows the spontaneous electrical activity that sets the heart’s rhythm. This selective inhibition reduces heart rate while preserving myocardial contractile force and systemic vascular resistance.

The specific dose of Ivabradine Accord is determined by the prescribing clinician based on the patient’s clinical status, heart‑rate targets, and tolerability. Dosage adjustments follow local prescribing guidelines and individual response.

Safety data for Ivabradine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both Ivabradine and beta‑blockers lower heart rate, but Ivabradine does so by selectively inhibiting the If current without affecting beta‑adrenergic receptors, blood pressure, or contractility. This makes it useful when beta‑blockers are contraindicated or insufficient, though it does not replace the broader cardiovascular effects of beta‑blockers.

Ivabradine Accord should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in humid environments.

Ivabradine Accord is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. It is typically taken with or without food as directed by the prescriber.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe visual disturbances (phosphenes), and rare cases of hypotension. Patients should be monitored for these events, especially during dose titration or when combined with other heart‑rate‑lowering agents.

Ivabradine should not be used in patients with a resting heart rate below 50 bpm, those with acute decompensated heart failure, severe hepatic impairment, or known hypersensitivity to the drug. Caution is also advised in patients with sick sinus syndrome or atrial fibrillation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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