Product image of Ivabradine Aurobindo (Ivabradine) supplied by GNH India

Ivabradine Aurobindo

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradine Aurobindo (Ivabradine)

Ivabradine, the active ingredient in Ivabradine Aurobindo, is an If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is used to manage chronic stable angina and heart failure with reduced ejection fraction in adult patients.
GNH India supplies Ivabradine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Ivabradine is employed in cardiovascular conditions that involve abnormal heart‑rate regulation.

  • Chronic stable angina: reduces the frequency of angina attacks by lowering heart rate without affecting contractility.
  • Heart failure with reduced ejection fraction: improves symptoms and may lower hospitalization risk by decreasing heart rate.
  • Patients unable to tolerate beta‑blockers: provides heart‑rate reduction as an alternative therapeutic option.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which controls spontaneous depolarisation. By blocking this inward sodium/potassium mixed current, the drug slows the pacemaker activity, producing a dose‑dependent reduction in heart rate while preserving myocardial contractility and arterial pressure.

Side Effects

Ivabradine may cause a range of adverse reactions, most of which are related to its heart‑rate lowering action and visual processing.

Common Side Effects

  • Phosphenes (transient visual bright spots)
  • Bradycardia (heart rate below 50 bpm)
  • Headache
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical intervention
  • Atrial fibrillation or other arrhythmias
  • Severe hypotension
  • Persistent visual disturbances
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

Before initiating therapy, clinicians should evaluate cardiac status and concomitant medications.

  • Cardiac monitoring: obtain baseline heart rate and ECG.
  • Hepatic impairment: avoid in severe liver disease.
  • Sick sinus syndrome: contraindicated unless a pacemaker is present.
  • CYP3A4 inhibitors: do not co‑administer strong inhibitors (e.g., ketoconazole).
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradine interacts with several drug classes that influence heart rate or its metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause excessive bradycardia.
  • Concomitant bradycardic agents (beta‑blockers, digoxin): risk of severe heart‑rate reduction.
  • Other If‑channel inhibitors: additive effect on heart‑rate control.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may increase plasma levels.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • QT‑prolonging drugs (e.g., sotalol, amiodarone): monitor ECG for arrhythmias.

Frequently Asked Questions

Ivabradine Aurobindo is indicated for the treatment of chronic stable angina and for heart failure with reduced ejection fraction. In both conditions it works by lowering heart rate, which helps to relieve chest pain in angina and improves symptoms and outcomes in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. By inhibiting this inward sodium/potassium mixed current, the drug slows spontaneous depolarisation, resulting in a controlled reduction of heart rate without decreasing the strength of cardiac contraction.

The dose of Ivabradine Aurobindo is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate target, and tolerance. The prescriber will select the appropriate strength and dosing schedule according to current guidelines and individual patient factors.

Safety of ivabradine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers reduce heart rate, but ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on adrenergic receptors and can lower blood pressure and contractility, making ivabradine a useful alternative when beta‑blockers are contraindicated or not tolerated.

Ivabradine Aurobindo tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Do not store in a refrigerator or freezer unless otherwise specified by the manufacturer.

Ivabradine Aurobindo is taken orally, usually with a glass of water. The tablet should be swallowed whole and not split, crushed, or chewed. Dosing times are typically aligned with the patient’s daily routine to maintain consistent heart‑rate control.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and persistent visual disturbances such as luminous phenomena. Patients should be monitored for these events, especially when initiating therapy or adjusting the dose.

Ivabradine Aurobindo is contraindicated in patients with severe hepatic impairment, sick sinus syndrome without a pacemaker, acute myocardial infarction, uncontrolled hypotension, or in those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to ivabradine or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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