Product image of Ivabradine Auxilto (Ivabradine Hydrochloride) supplied by GNH India

Ivabradine Auxilto

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradine Auxilto (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradine Auxilto, is an If channel inhibitor presented as an oral tablet for oral use. It selectively lowers heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients who require heart‑rate control and have been evaluated for suitability.

GNH India supplies Ivabradine Auxilto as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures reliable delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Auxilto Healthcare S.R.O.

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Indications & Clinical Uses

Ivabradine acts on the cardiac If channel to reduce heart rate, benefiting specific cardiovascular conditions.

  • Chronic stable angina: decreases the frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers heart rate to improve ventricular filling and reduce risk of hospitalization.
  • Patients intolerant to beta‑blockers: provides heart‑rate reduction without affecting myocardial contractility.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node by binding to the HCN channel pore. This reduces spontaneous depolarisation, leading to a slower heart rate while preserving myocardial contractility and blood pressure, thereby improving cardiac efficiency in conditions where heart‑rate control is therapeutic.

Side Effects

Adverse reactions may occur with ivabradine therapy. Patients should be monitored for any new symptoms.

Common Side Effects

  • Phosphenes (transient visual disturbances)
  • Bradycardia
  • Headache
  • Dizziness
  • Fatigue
  • Blurred vision

Serious or Rare Side Effects

  • Symptomatic severe bradycardia requiring medical intervention
  • Atrial fibrillation or other arrhythmias
  • Severe hypotension
  • Visual loss or retinal abnormalities
  • QT interval prolongation
  • Allergic skin reactions

Precautions & Warnings

Ivabradine requires careful patient assessment and monitoring.

  • Baseline heart rate assessment: ensure resting heart rate is ≥70 bpm before initiation.
  • Contraindicated in severe hepatic impairment: avoid use in patients with Child‑Pugh C liver disease.
  • Caution in sick sinus syndrome: monitor for excessive bradycardia.
  • Avoid concomitant strong CYP3A4 inhibitors: may increase plasma concentrations.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradine may interact with several drug classes; clinicians should review patient medication lists.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): can markedly increase ivabradine levels.
  • Other bradycardic agents (beta‑blockers, digoxin, diltiazem, verapamil): risk of excessive heart‑rate reduction.
  • Other If channel inhibitors: additive effect on heart rate.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole, erythromycin): may require dose adjustment.
  • Antihypertensive agents: monitor blood pressure and heart rate.
  • Diuretics: watch for electrolyte disturbances that could affect cardiac conduction.

Frequently Asked Questions

Ivabradine Auxilto contains ivabradine hydrochloride and is prescribed to lower heart rate in adults with chronic stable angina or heart failure with reduced ejection fraction. By reducing the heart rate, it helps relieve angina symptoms and improves cardiac efficiency in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, which is responsible for spontaneous pacemaker activity. Inhibiting this current slows the rate of depolarisation, resulting in a lower heart rate without decreasing the strength of heart muscle contraction.

The dose of ivabradine is individualized by the prescribing clinician based on the patient’s resting heart rate, clinical condition, and response to therapy. The prescriber determines the appropriate strength, frequency, and any necessary titration.

Safety data for ivabradine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Ivabradine Auxilto, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting beta‑adrenergic receptors. This means it does not influence blood pressure or contractility, making it useful when beta‑blockers are contraindicated or not tolerated.

Ivabradine Auxilto should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Do not store in a bathroom or near heat sources to maintain product stability.

Ivabradine Auxilto is taken orally, usually with a glass of water. It is typically administered twice daily, but the exact schedule and timing relative to meals are determined by the prescribing clinician.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and rare visual disturbances that may affect the retina. Patients should be instructed to report any episodes of dizziness, fainting, or visual changes promptly.

Ivabradine is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, acute myocardial infarction, unstable angina, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with a resting heart rate below 70 bpm unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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