Product image of Ivabradine Biogaran (Ivabradine) supplied by GNH India

Ivabradine Biogaran

Active Ingredient:
Ivabradine
Origin:
EU

Ivabradine Biogaran (Ivabradine)

Ivabradine, the active ingredient in Ivabradine Biogaran, is an If‑channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is used to treat chronic stable angina and heart failure with reduced ejection fraction in adult patients who experience symptomatic disease despite optimal therapy.

GNH India supplies Ivabradine Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for import and distribution.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

Ivabradine is an If‑channel inhibitor used in cardiovascular conditions that benefit from heart‑rate reduction.

  • Chronic stable angina: lowers heart rate, which reduces myocardial oxygen demand and consequently decreases the frequency and severity of angina episodes in patients with chronic stable angina.
  • Heart failure with reduced ejection fraction: decreases heart rate, improving ventricular filling time and cardiac efficiency, thereby alleviating symptoms and potentially reducing hospitalization rates in patients with HFrEF.

How It Works

  • Ivabradine selectively binds to the funny (If) current channels in the sinoatrial node, inhibiting the inward sodium/potassium mixed current responsible for spontaneous depolarization. By reducing the slope of phase 4 diastolic depolarization, the drug slows pacemaker activity without affecting myocardial contractility or intracardiac conduction, leading to a controlled reduction in resting heart rate. The effect is dose‑dependent and reversible, allowing heart‑rate modulation while preserving blood pressure and ventricular function.

Side Effects

Ivabradine may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Bradycardia: resting heart rate may fall below 50 beats/min.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo: especially on standing.

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical intervention.
  • Atrial fibrillation or other serious arrhythmias.
  • Severe hypotension or syncope.
  • Allergic reactions such as rash, angioedema, or anaphylaxis.

Precautions & Warnings

Before initiating Ivabradine, clinicians should consider several precautionary measures to ensure safe use.

  • Baseline heart rate assessment: confirm resting heart rate ≥ 60 bpm before starting therapy.
  • Concomitant bradycardic agents: avoid or adjust dose when used with beta‑blockers, digoxin, or calcium‑channel blockers.
  • Hepatic impairment: use with caution in patients with moderate to severe liver dysfunction.
  • Renal impairment: dose adjustment may be required in severe renal failure.
  • Pregnancy and lactation: safety not established; prescribe only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Ivabradine can interact with other medicines, altering its plasma concentration or additive pharmacodynamic effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, itraconazole): may markedly increase Ivabradine levels.
  • Other heart‑rate‑lowering drugs (beta‑blockers, digoxin, diltiazem, verapamil): risk of excessive bradycardia.
  • Concomitant use with other If‑channel blockers: not recommended.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole, erythromycin): may require dose adjustment.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Drugs that prolong QT interval (certain antiarrhythmics): monitor ECG.
  • Antihypertensives: observe for additive blood pressure lowering.

Frequently Asked Questions

Ivabradine Biogaran is prescribed to lower heart rate in adult patients with chronic stable angina and in those with heart failure with reduced ejection fraction. By reducing the heart’s pacing activity, it helps relieve angina symptoms and improves functional status in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, which is responsible for spontaneous pacemaker activity. Inhibition of this current slows the rate of diastolic depolarisation, leading to a controlled reduction in resting heart rate without affecting contractility or blood pressure.

The appropriate dose of Ivabradine Biogaran is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate targets, and relevant guidelines. Dosage adjustments may be needed for renal or hepatic impairment, and the prescriber will tailor the regimen to each individual.

Safety of Ivabradine in pregnancy and lactation has not been established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Ivabradine Biogaran. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both Ivabradine and beta‑blockers lower heart rate, but Ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on adrenergic receptors and also reduce contractile force. Ivabradine may be added when beta‑blockers alone do not achieve target heart rates or are not tolerated.

Store Ivabradine Biogaran at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct light, and avoid exposure to extreme heat or humidity to maintain product stability.

Ivabradine is taken orally as a tablet, usually with or without food. The tablet should be swallowed whole with a glass of water and not be chewed, crushed, or split unless specifically instructed by the prescriber.

The most serious adverse events include symptomatic bradycardia that may require medical intervention, atrial fibrillation or other serious arrhythmias, severe hypotension or syncope, and rare but severe visual disturbances or allergic reactions such as angioedema.

Ivabradine is contraindicated in patients with a resting heart rate below 60 bpm, those with sick‑sinus syndrome, severe hepatic impairment, or uncontrolled hypotension. It should also be avoided in individuals taking strong CYP3A4 inhibitors unless dose adjustments are made under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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