Product image of Ivabradine Chanelle Medical (Ivabradine Oxalate) supplied by GNH India

Ivabradine Chanelle Medical

Active Ingredient:
Ivabradine Oxalate
Origin:
EU

Ivabradine Chanelle Medical (Ivabradine Oxalate)

Ivabradine, the active ingredient in Ivabradine Chanelle Medical, is an If channel inhibitor presented as an oral tablet for oral use. It is indicated for chronic stable angina and for heart failure with reduced ejection fraction, helping to lower heart rate without affecting myocardial contractility.

GNH India supplies Ivabradine Chanelle Medical as a licensed, GDP‑compliant international pharmaceutical supplier, providing the EU‑origin product to hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance.

Manufacturer / TM Owner

Chanelle Medical Unlimited Company

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ivabradine is used to manage cardiac conditions where heart‑rate reduction improves outcomes.

  • Chronic stable angina: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction: improves symptoms and may decrease hospitalisation by decreasing heart rate.
  • Patients intolerant to beta‑blockers: offers an alternative mechanism to achieve heart‑rate control.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which is responsible for spontaneous depolarisation. By blocking this pacemaker current, the drug slows the firing rate of the SA node, leading to a reduction in resting heart rate while preserving myocardial contractility and blood pressure.

Side Effects

Common Side Effects

  • Bradycardia: unusually slow heart rate.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness.
  • Fatigue or general weakness.
  • Blurred vision.

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical intervention.
  • Atrial fibrillation or other arrhythmias.
  • Severe hypotension.
  • QT interval prolongation.
  • Allergic reactions such as rash or angioedema.
  • Hepatic dysfunction.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Cardiac monitoring: assess baseline heart rate and rhythm.
  • Hepatic impairment: avoid or adjust dose in severe liver disease.
  • Sick sinus syndrome: contraindicated due to risk of excessive bradycardia.
  • Concomitant bradycardic agents: monitor for additive effects.
  • Pregnancy and lactation: use only if potential benefit justifies the risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ivabradine may interact with several medicines; review patient medication lists carefully.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): can markedly increase ivabradine plasma levels.
  • Other bradycardic agents (e.g., beta‑blockers, digoxin): may cause excessive heart‑rate reduction.
  • Other If channel inhibitors (e.g., ranolazine): additive effect on heart‑rate control.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil): may raise ivabradine concentrations.
  • QT‑prolonging drugs: increase risk of cardiac arrhythmias.
  • Certain antidepressants affecting CYP3A4 (e.g., fluoxetine): require periodic ECG monitoring.

Frequently Asked Questions

Ivabradine Chanelle Medical is prescribed to lower heart rate in patients with chronic stable angina and in those with heart failure that has a reduced ejection fraction. By slowing the heart’s pacemaker activity, it helps relieve chest pain episodes and may improve functional capacity in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the natural pacemaker of the heart. Inhibiting this current reduces the spontaneous depolarisation rate of the node, leading to a slower heart rhythm while leaving contractile strength and blood pressure largely unchanged.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s clinical condition, heart‑rate targets, and tolerance. Healthcare professionals adjust the regimen according to approved labeling and patient response.

The safety of ivabradine in pregnancy and lactation has not been established. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but they act via different mechanisms. Beta‑blockers reduce heart rate by blocking adrenergic receptors and also lower blood pressure, whereas ivabradine selectively inhibits the If current without affecting contractility or blood pressure. Ivabradine is often considered when patients cannot tolerate beta‑blockers or need additional rate reduction.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light, and ensure the container is tightly closed until use.

Ivabradine Chanelle Medical is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not crushed or chewed.

The most serious adverse events include symptomatic bradycardia, atrial fibrillation, severe hypotension, and rare cases of QT‑interval prolongation. Patients should be monitored for signs of excessively slow heart rate, palpitations, dizziness, or fainting, and seek medical attention promptly if these occur.

Ivabradine is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, acute myocardial infarction, uncontrolled hypotension, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to ivabradine or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.