Product image of Ivabradine Doc Generici (Ivabradine Hydrochloride) supplied by GNH India

Ivabradine Doc Generici

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradine Doc Generici (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradine Doc Generici, is an If channel inhibitor presented as an oral tablet for oral use. It is indicated for chronic stable angina pectoris and heart failure with reduced ejection fraction in appropriate patients.

GNH India supplies Ivabradine Doc Generici as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

  • Ivabradine is employed in cardiovascular conditions where heart‑rate reduction improves outcomes.
  • Chronic stable angina pectoris: decreases frequency of angina attacks and improves exercise tolerance.
  • Heart failure with reduced ejection fraction: lowers heart rate, enhancing functional capacity and reducing hospitalisations.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows spontaneous depolarisation and reduces heart rate without altering myocardial contractility or blood pressure, thereby improving cardiac efficiency in angina and heart‑failure patients.

Side Effects

Adverse reactions may occur with ivabradine therapy.

Common Side Effects

  • Visual disturbances (phosphenes or luminous phenomena)
  • Bradycardia
  • Headache
  • Dizziness
  • Fatigue
  • Blurred vision

Serious or Rare Side Effects

  • Severe bradycardia requiring medical intervention
  • Atrial fibrillation or other arrhythmias
  • Symptomatic hypotension
  • Persistent visual loss
  • Hepatic dysfunction
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

  • Before initiating ivabradine, consider the following precautions.
  • Cardiac monitoring: assess resting heart rate and ECG prior to therapy and periodically thereafter.
  • Concomitant bradycardic agents: avoid excessive heart‑rate reduction when used with beta‑blockers or digoxin.
  • Severe hepatic impairment: use with caution; dose adjustment may be required.
  • Pregnancy and lactation: safety not established; avoid unless benefit outweighs potential risk.
  • Drug interactions: review concomitant CYP3A4 inhibitors or inducers.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Ivabradine may interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – may increase ivabradine exposure.
  • Other agents that markedly lower heart rate (e.g., beta‑blockers, digoxin) – risk of severe bradycardia.
  • Concomitant use with other If‑channel inhibitors – additive effect on heart‑rate reduction.

Moderate Interactions (Monitor Closely):\n- Moderate CYP3A4 inhibitors (e.g., erythromycin) – may modestly raise plasma levels.

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine) – may reduce efficacy.
  • Diuretics or antihypertensives – monitor blood pressure and electrolytes.

Frequently Asked Questions

Ivabradine Doc Generici is prescribed to lower heart rate in patients with chronic stable angina pectoris and in those with heart failure that has a reduced ejection fraction. By slowing the sinus node, it helps reduce angina episodes and improves functional capacity in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, which is responsible for spontaneous pacemaker activity. Inhibition of this current slows the depolarisation rate, leading to a reduction in heart rate without affecting contractility or blood pressure.

The dose of ivabradine is individualized by the prescribing clinician based on the patient’s heart‑rate, clinical condition, and tolerance. The prescriber determines the appropriate strength, frequency and any necessary adjustments during therapy.

Safety data for ivabradine during pregnancy and lactation are limited. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To request Ivabradine Doc Generici, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by directly inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on adrenergic receptors and have broader cardiovascular effects, which may be advantageous or limiting depending on the patient’s comorbidities.

Ivabradine tablets should be stored at ambient temperature, preferably below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Ivabradine is taken orally, usually as a tablet swallowed whole with a glass of water. It is generally administered with or without food, as directed by the prescriber, and should be taken at the same times each day to maintain consistent blood levels.

The most serious adverse events include severe bradycardia, atrial fibrillation or other arrhythmias, and visual disturbances such as luminous phenomena or persistent loss of vision. Patients should report any symptoms of fainting, palpitations, or visual changes promptly to their healthcare provider.

Ivabradine is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, sinoatrial block, or resting heart rates below 50 beats per minute. Caution is also advised for individuals taking strong CYP3A4 inhibitors or other medications that significantly lower heart rate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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