Product image of Ivabradine Generics [uk] (Ivabradine Oxalate) supplied by GNH India

Ivabradine Generics [uk]

Active Ingredient:
Ivabradine Oxalate
Origin:
EU

Ivabradine Generics [uk] (Ivabradine Oxalate)

Ivabradine, the active ingredient in Ivabradine Generics, is a If channel inhibitor presented as an oral tablet for oral use. It reduces heart rate and is used in chronic stable angina and heart failure with reduced ejection fraction in adults.

GNH India supplies Ivabradine Generics as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generics [uk] Limited

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Indications & Clinical Uses

Ivabradine acts on the cardiac If current to lower heart rate in specific cardiovascular conditions.

  • Chronic stable angina: improves exercise tolerance by reducing heart rate.
  • Heart failure with reduced ejection fraction: decreases hospitalization risk through heart‑rate reduction.
  • Angina pectoris: alleviates chest pain by limiting myocardial oxygen demand.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows spontaneous depolarisation. This reduces heart rate without affecting myocardial contractility or blood pressure, thereby decreasing cardiac oxygen consumption and improving symptoms in angina and heart‑failure patients.

Side Effects

Adverse reactions may occur with ivabradine therapy.

Common Side Effects

  • Bradycardia: heart rate falls below expected levels.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache: mild to moderate intensity.
  • Dizziness or light‑headedness.

Serious or Rare Side Effects

  • Severe bradycardia requiring medical attention.
  • Atrial fibrillation or other arrhythmias.
  • Symptomatic hypotension or heart block.

Precautions & Warnings

Use ivabradine with careful clinical monitoring.

  • Heart‑rate monitoring: check resting rate before and during therapy.
  • Hepatic impairment: avoid or adjust dose in severe liver disease.
  • Concomitant bradycardic agents: use caution with beta‑blockers or calcium‑channel blockers.
  • Sick sinus syndrome: contraindicated.
  • Discontinue if resting heart rate falls below 50 bpm.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradine may interact with several medicines.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase ivabradine exposure.
  • Concomitant beta‑blockers or other heart‑rate‑lowering drugs: risk of excessive bradycardia.
  • Diltiazem or verapamil: potentiate ivabradine effects via CYP3A4.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, clarithromycin): may raise plasma levels.
  • Digoxin: combined use may enhance bradycardic risk.

Frequently Asked Questions

Ivabradine Generics is prescribed to lower heart rate in adults with chronic stable angina and in patients with heart failure with reduced ejection fraction, helping to improve symptoms and reduce cardiovascular events.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, slowing the pacemaker activity of the heart. This reduces the resting heart rate without affecting the strength of cardiac contraction.

The dose of ivabradine is individualized by the prescribing clinician based on the patient’s heart‑rate response, clinical condition, and tolerability. Exact dosing regimens are not provided here.

Safety data for ivabradine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

Enquire about Ivabradine Generics by submitting a request on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure, whereas beta‑blockers act on adrenergic receptors and have broader cardiovascular effects.

Store ivabradine tablets at room temperature, below 25 °C, in the original packaging and protect them from moisture and direct sunlight to maintain product stability.

Ivabradine is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing and frequency depend on the individual treatment plan.

Serious risks include severe bradycardia, atrial fibrillation, symptomatic hypotension, and heart block. Patients should be monitored for these events, especially when combined with other heart‑rate‑lowering agents.

Ivabradine is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, acute decompensated heart failure, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with a resting heart rate below 50 bpm unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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