Product image of Ivabradina Chemo Ibérica (Ivabradine Hydrochloride) supplied by GNH India

Ivabradina Chemo Ibérica

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradina Chemo Ibérica (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradina Chemo Ibérica, is a If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is indicated for chronic stable angina and heart failure with reduced ejection fraction in adult patients.
GNH India supplies Ivabradina Chemo Ibérica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chemo Ibérica, S.A.

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Indications & Clinical Uses

Ivabradina Chemo Ibérica acts on the cardiac If current to reduce heart rate in several cardiovascular conditions.

  • Chronic stable angina: decreases the frequency of angina attacks by lowering myocardial oxygen demand.
  • Heart failure with reduced ejection fraction: improves symptoms and reduces hospitalisations through heart‑rate reduction.
  • Patients intolerant to beta‑blockers: provides an alternative means of controlling heart rate without beta‑adrenergic blockade.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which controls spontaneous pacemaker activity. By blocking this inward sodium/potassium mixed current, the drug slows diastolic depolarisation, leading to a reduction in heart rate while preserving myocardial contractility and blood pressure.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Phosphenes (transient visual disturbances)
  • Headache
  • Dizziness
  • Fatigue
  • Bradycardia (asymptomatic)
  • Nausea

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical intervention
  • Atrial fibrillation or other arrhythmias
  • Severe hypotension
  • Persistent visual impairment
  • Worsening angina or myocardial infarction
  • Heart failure decompensation

Precautions & Warnings

Careful assessment and monitoring are required before and during therapy.

  • Heart rate monitoring: ensure resting heart rate remains above 50 bpm.
  • Severe hepatic impairment: avoid or use with caution.
  • Sick sinus syndrome or atrioventricular block: contraindicated.
  • Concomitant strong CYP3A4 inhibitors: avoid due to increased exposure.
  • Renal impairment: dose adjustment may be needed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ivabradina Chemo Ibérica can interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) – may raise plasma levels.
  • Other bradycardic agents (beta‑blockers, digoxin, diltiazem, verapamil) – risk of excessive heart‑rate reduction.
  • Certain anti‑arrhythmic drugs (e.g., amiodarone) – can potentiate bradycardia.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, clarithromycin) – monitor heart rate.
  • Antihypertensive agents – watch for additive blood‑pressure lowering.
  • Drugs affecting QT interval – observe ECG for changes.
  • Herbal supplements containing St. John’s wort – may reduce efficacy.

Frequently Asked Questions

Ivabradina Chemo Ibérica is prescribed to manage chronic stable angina and heart failure with reduced ejection fraction. In both conditions it works by lowering the heart rate, which reduces myocardial oxygen demand and improves symptoms such as chest pain and exercise intolerance.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. By inhibiting this inward sodium/potassium current, the drug slows the spontaneous depolarisation of pacemaker cells, leading to a reduced heart‑rate without affecting contractility or blood pressure.

The dose of Ivabradina Chemo Ibérica is determined by the prescribing clinician based on the patient’s clinical status, heart‑rate targets, and tolerance. Dosage adjustments may be required after assessing heart‑rate response and any adverse effects.

Safety data for ivabradine in pregnancy and lactation are limited, and the product is generally not recommended for use in pregnant or nursing women unless the potential benefit justifies the potential risk. Clinicians should discuss alternatives and risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting beta‑adrenergic receptors. This means it does not influence contractility or blood pressure as beta‑blockers do, making it useful for patients who cannot tolerate beta‑blockade.

Ivabradina Chemo Ibérica should be stored at room temperature, below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat and direct sunlight to maintain stability.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not chewed or crushed, unless the prescriber provides specific instructions.

Serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and worsening angina that could lead to myocardial infarction. Patients should be monitored for these events, especially when initiating therapy or adjusting the dose.

Ivabradina Chemo Ibérica is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, second‑ or third‑degree atrioventricular block, uncontrolled hypotension, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to ivabradine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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