Product image of Ivabradine Mercury Pharmaceuticals Limited (Ivabradine Hydrochloride) supplied by GNH India

Ivabradine Mercury Pharmaceuticals Limited

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradine Mercury Pharmaceuticals Limited (Ivabradine Hydrochloride)

Ivabradine, the active ingredient in Ivabradine Mercury Pharmaceuticals Limited, is a If channel inhibitor presented as an oral dosage form for oral use. It is used to lower heart rate in patients with chronic stable angina and in heart failure with reduced ejection fraction.

GNH India supplies Ivabradine Mercury Pharmaceuticals Limited as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mercury Pharmaceuticals Ltd.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ivabradine is an If channel inhibitor used in cardiovascular conditions.

  • Chronic stable angina: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction: improves symptoms and lowers risk of hospitalization.
  • Elevated resting heart rate: helps achieve target heart‑rate control in appropriate patients.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows depolarisation of pacemaker cells. By reducing the slope of phase 4 depolarisation, the drug lowers spontaneous heart‑rate without affecting myocardial contractility or blood pressure, providing rate control in angina and heart‑failure settings.

Side Effects

Ivabradine may cause a range of adverse reactions, most of which are related to its heart‑rate‑lowering activity and visual pathways.

Common Side Effects

  • Phosphenes (transient visual disturbances).
  • Bradycardia (slow heart rate).
  • Headache.
  • Dizziness.
  • Fatigue.
  • Blurred vision.

Serious or Rare Side Effects

  • Severe bradycardia requiring medical attention.
  • Atrial fibrillation or other arrhythmias.
  • Symptomatic hypotension.
  • Persistent visual disturbances affecting daily activities.
  • Severe allergic reactions (rash, swelling, anaphylaxis).
  • Hepatic dysfunction (elevated liver enzymes).

Precautions & Warnings

When prescribing ivabradine, clinicians should consider several safety measures.

  • Heart‑rate monitoring: ensure resting heart rate remains above the recommended minimum.
  • Hepatic impairment: use with caution in patients with moderate to severe liver disease.
  • Sick‑sinus syndrome: avoid in patients with pre‑existing sinus node dysfunction.
  • Concomitant bradycardic agents: adjust dose or monitor closely when used with beta‑blockers or digoxin.
  • Renal impairment: consider dose adjustment in severe renal dysfunction.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ivabradine interacts with several drug classes that can modify its effect on heart rate and metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase ivabradine plasma levels.
  • Other bradycardic agents (beta‑blockers, digoxin, diltiazem, verapamil): risk of excessive heart‑rate reduction.
  • CYP3A4 inhibitors combined with diltiazem/verapamil: additive effect on metabolism.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce ivabradine efficacy.

  • Antihypertensive agents: monitor blood pressure and heart rate.
  • Antiarrhythmic drugs (e.g., amiodarone): may require dose adjustment.

Frequently Asked Questions

Ivabradine is prescribed to lower heart rate in patients with chronic stable angina and in those with heart failure with reduced ejection fraction. By reducing the heart’s pacing activity, it helps relieve angina symptoms and improves functional status in heart‑failure patients.

Ivabradine selectively blocks the funny (If) current in the sinoatrial node, the heart’s natural pacemaker. This inhibition slows the spontaneous depolarisation of pacemaker cells, leading to a lower resting heart rate without affecting contractility or blood pressure.

The appropriate dose of Ivabradine is determined by the prescribing clinician based on the patient’s heart‑rate, clinical condition, and any concomitant therapies. Dosage adjustments are made according to therapeutic response and tolerability.

Safety data for Ivabradine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Ivabradine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both Ivabradine and beta‑blockers lower heart rate, but Ivabradine does so by directly inhibiting the If current without affecting contractility or blood pressure. Beta‑blockers act on adrenergic receptors and have broader cardiovascular effects, which may be advantageous or limiting depending on the patient’s overall condition.

Ivabradine should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain stability and potency.

Ivabradine is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not crushed or chewed.

The most serious risks include severe bradycardia, symptomatic hypotension, atrial fibrillation, and persistent visual disturbances. Patients should be monitored for these events, especially when initiating therapy or adjusting the dose.

Ivabradine is contraindicated in patients with severe hepatic impairment, sick‑sinus syndrome, acute myocardial infarction, unstable angina, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with a resting heart rate below the recommended minimum.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Ivabradine Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT