Product image of Ivabradine Ranbaxy (Ivabradine Hydrochloride) supplied by GNH India

Ivabradine Ranbaxy

Active Ingredient:
Ivabradine Hydrochloride
Origin:
EU

Ivabradine Ranbaxy (Ivabradine Hydrochloride)

Ivabradine hydrochloride, the active ingredient in Ivabradine Ranbaxy, is a If channel inhibitor presented as an oral tablet for oral use. It is used to lower heart rate in patients with chronic stable angina and heart failure with reduced ejection fraction.
GNH India supplies Ivabradine Ranbaxy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ranbaxy Poland Sp. Zo.O

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Indications & Clinical Uses

  • Ivabradine Ranbaxy acts on the cardiac If current to manage conditions where heart‑rate reduction is beneficial.
  • Chronic stable angina: reduces the frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction: improves symptoms and exercise capacity by decreasing myocardial oxygen demand.
  • Symptomatic tachycardia in angina patients: provides rate control when beta‑blockers are contraindicated.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sinoatrial node, which slows depolarisation of pacemaker cells. This results in a dose‑dependent reduction of resting heart rate without affecting myocardial contractility, ventricular repolarisation, or blood pressure, thereby decreasing cardiac oxygen consumption.

Side Effects

Ivabradine may cause a range of adverse reactions.

Common Side Effects

  • Bradycardia: resting heart rate falls below 50 bpm.
  • Visual disturbances (phosphenes): transient luminous phenomena.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Fatigue or general weakness.
  • Blurred vision.

Serious or Rare Side Effects

  • Severe bradycardia requiring medical intervention.
  • Atrial fibrillation or other supraventricular arrhythmias.
  • Symptomatic hypotension.
  • High‑grade atrioventricular block.
  • Acute coronary syndrome in susceptible patients.

Precautions & Warnings

  • Before initiating therapy, clinicians should assess cardiac status and monitor heart rate.
  • Monitor heart rate: ensure resting HR > 50 bpm before starting.
  • Avoid in severe hepatic impairment: dose adjustment may be required.
  • Caution with concomitant beta‑blockers: increased risk of excessive bradycardia.
  • Assess for visual disorders: discontinue if persistent phosphenes occur.
  • Pregnancy and lactation: use only if potential benefit justifies risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Ivabradine's pharmacokinetics can be altered by several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may markedly increase exposure.
  • Co‑administration with other heart‑rate‑lowering agents (beta‑blockers, digoxin, verapamil): risk of severe bradycardia.
  • Concomitant use with diltiazem: can elevate plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Antihypertensive agents: monitor blood pressure for additive effects.
  • Alcohol: may potentiate bradycardic response.

Frequently Asked Questions

Ivabradine Ranbaxy is indicated for chronic stable angina and for heart failure with reduced ejection fraction. In both settings it works by lowering heart rate, which reduces myocardial oxygen demand and can improve symptoms such as chest pain and exercise intolerance.

Ivabradine hydrochloride selectively blocks the funny (If) current in the sinoatrial node. By inhibiting this pacemaker current, the drug slows the spontaneous depolarisation of heart‑rate‑controlling cells, leading to a reduction in resting heart rate without affecting contractility or blood pressure.

The appropriate dose of Ivabradine Ranbaxy is determined by the prescribing clinician based on the patient’s clinical condition, heart‑rate response, and tolerability. Dosage adjustments may be needed for renal or hepatic impairment, and the prescriber will provide specific instructions.

The safety of ivabradine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so without affecting blood pressure or myocardial contractility. It is often used when beta‑blockers are contraindicated, not tolerated, or when additional rate control is needed alongside beta‑blocker therapy.

Ivabradine Ranbaxy tablets should be stored at ambient temperature, below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

The medication is taken orally, usually with or without food, as directed by the prescribing physician. Tablets should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise instructed.

The most serious risks include severe bradycardia, atrial fibrillation, high‑grade atrioventricular block, and symptomatic hypotension. Patients should be monitored for signs of these events, especially when initiating therapy or adjusting doses.

Ivabradine is contraindicated in patients with severe hepatic impairment, acute decompensated heart failure, sick sinus syndrome, or a resting heart rate below 50 bpm. It should also be avoided in individuals taking strong CYP3A4 inhibitors unless dose adjustments are made.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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