Product image of Ivabradine Viatris (Ivabradine Oxalate) supplied by GNH India

Ivabradine Viatris

Active Ingredient:
Ivabradine Oxalate
Origin:
EU

Ivabradine Viatris (Ivabradine Oxalate)

Ivabradine, the active ingredient in Ivabradine Viatris, is a If channel inhibitor presented as an oral tablet for oral use. It is used to manage chronic heart failure and stable angina pectoris in adult patients. The drug reduces heart rate by selectively inhibiting the funny (If) current in the sino‑atrial node without affecting myocardial contractility or blood pressure.

GNH India supplies Ivabradine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality compliance with EU standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

Ivabradine acts on the cardiac conduction system by lowering heart rate, and is indicated for the following conditions:

  • Chronic heart failure: improves symptoms, exercise tolerance and reduces hospitalization risk.
  • Stable angina pectoris: decreases frequency of angina attacks and need for nitroglycerin.
  • Heart failure with reduced ejection fraction: provides mortality benefit when combined with standard therapy.

How It Works

  • Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, which drives spontaneous depolarization during diastole. Inhibition of this pacemaker current slows impulse generation, producing a dose‑dependent reduction in heart rate while preserving myocardial contractility and systemic blood pressure. The effect is specific to the If channel and does not interfere with other cardiac ion channels.

Side Effects

Ivabradine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Bradycardia
  • Visual disturbances (phosphenes)
  • Headache
  • Dizziness
  • Fatigue
  • Blurred vision

Serious or Rare Side Effects

  • Symptomatic severe bradycardia
  • Atrial fibrillation
  • Severe visual impairment
  • Allergic reactions such as rash or angioedema
  • QT interval prolongation

Precautions & Warnings

When prescribing Ivabradine, clinicians should observe the following precautions.

  • Cardiac monitoring: assess resting heart rate before initiation and periodically during therapy.
  • Contraindicated in severe hepatic impairment: avoid use in patients with Child‑Pugh class C liver disease.
  • Caution with sick sinus syndrome: do not use in patients with pre‑existing sinus node dysfunction.
  • Avoid concomitant strong CYP3A4 inhibitors: such as ketoconazole, clarithromycin, which can increase plasma levels.
  • Store at ambient temperature: keep tablets in the original container, protect from moisture and light.

Avoid Interactions

Ivabradine interacts with several medicines; notable interactions are grouped by clinical relevance.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise ivabradine concentrations and increase risk of bradycardia.
  • Other bradycardic agents (beta‑blockers, digoxin, verapamil): additive heart‑rate lowering effect.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce ivabradine exposure.
  • Verapamil or diltiazem: moderate CYP3A4 inhibition, may require dose adjustment.
  • Antidepressants affecting CYP3A4 (e.g., fluoxetine): monitor for increased effects.

Frequently Asked Questions

Ivabradine Viatris is prescribed to treat chronic heart failure and stable angina pectoris. By lowering heart rate, it helps improve exercise capacity in heart‑failure patients and reduces the frequency of angina episodes in patients with coronary artery disease.

Ivabradine works by selectively inhibiting the funny (If) current in the sino‑atrial node, the pacemaker of the heart. This inhibition slows the spontaneous depolarisation of cardiac cells, resulting in a lower heart rate without compromising contractile strength or blood pressure.

The appropriate dose of Ivabradine Viatris is determined by the prescribing clinician based on the patient’s heart‑rate, clinical condition and response to therapy. Dosage adjustments may be required during treatment, and patients should follow the prescriber’s instructions exactly.

Safety data for ivabradine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Ivabradine Viatris, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by directly inhibiting the If current without affecting beta‑adrenergic receptors. This means it does not influence blood pressure or contractility, making it a useful adjunct when beta‑blockers alone are insufficient or not tolerated.

Ivabradine tablets should be stored at ambient temperature, below 25 °C, in the original container. Keep them away from moisture and direct light, and ensure the packaging remains tightly closed until use.

Ivabradine Viatris is taken orally, usually with a glass of water. The tablets are swallowed whole and should be taken with or without food as directed by the prescriber. Consistency in timing each dose helps maintain stable blood‑level concentrations.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe visual disturbances, and rare allergic reactions. Patients should report any episodes of dizziness, fainting, palpitations, or visual changes to their healthcare provider promptly.

Ivabradine is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, acute myocardial infarction, unstable angina, or those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with a resting heart rate below the threshold set by the prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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