Product image of Ivabradine Viatris (Ivabradine Oxalate) supplied by GNH India

Ivabradine Viatris

Active Ingredient:
Ivabradine Oxalate
Origin:
EU

Ivabradine Viatris (Ivabradine Oxalate)

Ivabradine, the active ingredient in Ivabradine Viatris, is an If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is used in patients with chronic stable angina pectoris and in certain heart‑failure patients.
GNH India supplies Ivabradine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Ivabradine acts on the cardiac If current to reduce heart rate in several cardiovascular conditions.

  • Chronic stable angina pectoris: decreases frequency of angina attacks by lowering heart rate.
  • Heart failure with reduced ejection fraction (NYHA class II–III): improves symptoms and may reduce hospitalisation by reducing heart rate.
  • Patients intolerant to beta‑blockers: provides an alternative mechanism for heart‑rate control.

How It Works

  • Ivabradine selectively inhibits the funny (If) current in the sino‑atrial node, which slows depolarisation of pacemaker cells. This reduction in automaticity lowers heart rate without affecting myocardial contractility, ventricular repolarisation, or blood pressure, allowing targeted heart‑rate control in angina and heart‑failure patients.

Side Effects

Common Side Effects

  • Visual disturbances (phosphenes or luminous phenomena)
  • Bradycardia (slow heart rate)
  • Headache
  • Dizziness
  • Fatigue
  • Blurred vision

Serious or Rare Side Effects

  • Symptomatic bradycardia requiring medical intervention
  • Atrial fibrillation or other arrhythmias
  • Severe hypotension
  • Persistent visual impairment
  • Heart block or conduction abnormalities
  • Severe allergic reactions (anaphylaxis).

Precautions & Warnings

Before initiating therapy, assess baseline heart rate and cardiac function.

  • Monitor heart rate: ensure resting rate is ≥60 bpm before starting.
  • Avoid in severe hepatic impairment: dose adjustment may be required.
  • Use caution in patients with sick sinus syndrome or atrioventricular block.
  • Avoid concomitant strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin).
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ivabradine may interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (ketoconazole, clarithromycin, itraconazole) – may increase plasma levels.
  • Other heart‑rate lowering agents (beta‑blockers, digoxin, diltiazem, verapamil) – risk of excessive bradycardia.
  • Certain anti‑arrhythmic drugs (e.g., amiodarone) – may potentiate conduction effects.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (rifampicin, carbamazepine, phenytoin) – may reduce efficacy.
  • Antihypertensive agents (ACE inhibitors, ARBs) – monitor blood pressure.
  • Diuretics – watch for electrolyte disturbances that could affect cardiac rhythm.

Frequently Asked Questions

Ivabradine Viatris is prescribed to lower heart rate in patients with chronic stable angina pectoris and in those with heart failure with reduced ejection fraction (NYHA class II–III). It may also be considered when beta‑blockers are not tolerated, providing an alternative method to control heart rate.

Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, the pacemaker of the heart. By inhibiting this current, the drug slows the spontaneous depolarisation of pacemaker cells, resulting in a reduced heart rate without affecting the strength of cardiac contraction.

The dosage of Ivabradine Viatris is determined by the prescribing clinician based on the individual’s clinical condition, heart‑rate response, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for ivabradine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Ivabradine Viatris, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting myocardial contractility or blood pressure. Beta‑blockers act on adrenergic receptors and have broader cardiovascular effects, which may be advantageous or limiting depending on the patient’s comorbidities.

Ivabradine Viatris tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency.

Ivabradine Viatris is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. Dosing times are typically aligned with the patient’s daily routine, and the medication should be taken consistently each day.

The most serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and rare visual disturbances that may be persistent. Patients should be monitored for these events, especially when initiating therapy or when combined with other heart‑rate‑lowering agents.

Ivabradine Viatris is contraindicated in patients with severe hepatic impairment, sick sinus syndrome, second‑ or third‑degree atrioventricular block, uncontrolled hypotension, or in those taking strong CYP3A4 inhibitors. It should also be avoided in individuals with known hypersensitivity to ivabradine or any excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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