Product image of Ivergalen (Ivermectin) supplied by GNH India

Ivergalen

Active Ingredient:
Ivermectin
Origin:
EU

Ivergalen (Ivermectin)

Ivermectin, the active ingredient in Ivergalen, is an anthelmintic (macrocyclic lactone) presented as an oral tablet for systemic use. It is employed to treat parasitic infections such as onchocerciasis, strongyloidiasis, scabies and pediculosis in appropriate patient populations.

GNH India supplies Ivergalen as a licensed, GDP‑compliant international pharmaceutical supplier, adhering to EU manufacturing standards and providing the product to hospitals, pharmacies and clinics worldwide through regulated distribution channels. All batches undergo rigorous quality testing to ensure potency and safety in accordance with pharmacopeial specifications.

Manufacturer / TM Owner

Galenicum Derma S.L.

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Indications & Clinical Uses

Ivermectin is an anthelmintic used to treat several parasitic infections.

  • Onchocerciasis: reduces microfilarial load and prevents disease progression.
  • Strongyloidiasis: eradicates intestinal larvae and prevents hyperinfection.
  • Scabies: eliminates Sarcoptes scabiei mites, relieving skin lesions.
  • Pediculosis: kills head lice, controlling infestation.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels in invertebrate nerve and muscle cells, increasing chloride ion influx, causing hyperpolarization, paralysis and death of the parasite. At higher concentrations it may also interact with mammalian GABA receptors, contributing to its safety profile when used at therapeutic doses.

Side Effects

Adverse reactions may occur with ivermectin therapy.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Dizziness: transient light‑headedness.
  • Abdominal pain: cramping or discomfort.
  • Diarrhea: loose stools.
  • Pruritus: mild skin itching.
  • Headache: mild to moderate.

Serious or Rare Side Effects

  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Neurologic toxicity: seizures, ataxia, or altered consciousness.
  • Hypotension: marked drop in blood pressure.
  • Anaphylaxis: acute allergic reaction requiring emergency care.

Precautions & Warnings

Safety considerations should be observed before prescribing ivermectin.

  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown excretion; consider potential infant exposure.
  • Liver disease: use with caution and monitor hepatic function.
  • Concomitant CNS depressants: may increase neurotoxicity risk.
  • Drug interactions: review for strong CYP3A4 inhibitors and P‑gp inhibitors.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Ivermectin may interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise ivermectin plasma levels.
  • P‑glycoprotein inhibitors: increase central nervous system exposure.
  • Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., carbamazepine): may reduce ivermectin efficacy.
  • Macrolide antibiotics: moderate effect on metabolism.
  • Alcohol: may augment CNS depression.

Frequently Asked Questions

Ivergalen, containing ivermectin, is prescribed for parasitic infections such as onchocerciasis (river blindness), strongyloidiasis, scabies and pediculosis (lice infestation). It targets the parasites responsible for these diseases and helps eliminate them under medical supervision.

Ivermectin binds to glutamate‑gated chloride channels in the nervous system of parasites, causing an influx of chloride ions. This hyperpolarizes the cells, leading to paralysis and death of the parasite, while having limited activity on human cells at therapeutic doses.

The exact dose of Ivergalen is determined by the prescribing clinician based on the specific indication, patient weight, age and clinical condition. Healthcare professionals follow approved guidelines and adjust the regimen as needed for each individual case.

Safety data for ivermectin in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Ivergalen product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivergalen (ivermectin) belongs to the macrocyclic lactone class and offers a broad spectrum against several parasites. Compared with older agents like albendazole, ivermectin often requires fewer doses and has a distinct mechanism targeting chloride channels, making it a preferred option for the listed indications.

Ivergalen should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its potency throughout its shelf life.

Ivergalen is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule depends on the condition being treated and the dose prescribed by the healthcare professional.

Serious adverse events, though rare, can include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity, neurologic toxicity (e.g., seizures), marked hypotension and anaphylaxis. Patients should seek immediate medical attention if they experience any of these symptoms.

Ivergalen is contraindicated in individuals with known hypersensitivity to ivermectin or any component of the formulation. Caution is advised for patients with significant liver disease, pregnant women, and those taking strong CYP3A4 or P‑gp inhibitors unless the prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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