Product image of Ivermectin Exeltis (Ivermectin) supplied by GNH India

Ivermectin Exeltis

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectin Exeltis (Ivermectin)

Ivermectin, the active ingredient in Ivermectin Exeltis, is an anthelmintic presented as an oral formulation for systemic use. It is employed to treat parasitic infections such as onchocerciasis, strongyloidiasis, cutaneous larva migrans and scabies in affected patients.

GNH India supplies Ivermectin Exeltis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution. Clients benefit from reliable logistics, batch traceability, and responsive technical support throughout the supply chain.

Manufacturer / TM Owner

Exeltis Slovakia

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Indications & Clinical Uses

  • Ivermectin is an anthelmintic that targets parasitic infections affecting the skin and subcutaneous tissues.
  • Onchocerciasis: reduces microfilarial load and prevents disease progression.
  • Strongyloidiasis: eliminates intestinal larvae and prevents hyperinfection.
  • Cutaneous larva migrans: resolves migrating skin lesions caused by hookworm larvae.
  • Scabies: eradicates Sarcoptes scabiei infestation and relieves itching.

How It Works

  • Ivermectin binds with high affinity to glutamate‑gated chloride channels that are present in the nerve and muscle cells of many invertebrate parasites. This binding increases the permeability of the cell membrane to chloride ions, causing hyperpolarization, paralysis of the parasite’s musculature, and ultimately death of the organism. The drug has limited affinity for mammalian GABA receptors, which contributes to its safety profile in humans.

Side Effects

Adverse reactions to Ivermectin Exeltis are generally mild, but serious events can occur.

Common Side Effects

  • Nausea: mild stomach upset.
  • Diarrhea: loose stools.
  • Dizziness: transient light‑headedness.
  • Itching: mild skin pruritus.

Serious or Rare Side Effects

  • Severe skin rash: including Stevens‑Johnson syndrome.
  • Liver injury: hepatitis or elevated liver enzymes.
  • Neurologic effects: seizures, altered consciousness, or visual disturbances.

Precautions & Warnings

  • When prescribing Ivermectin Exeltis, clinicians should consider several safety measures.
  • Assess contraindications: screen for known hypersensitivity to ivermectin.
  • Review hepatic function: adjust use in patients with severe liver disease.
  • Monitor for drug interactions: be aware of concomitant medications that may affect ivermectin levels.
  • Use with caution in pregnancy: limited data, weigh benefits versus risks.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ivermectin may interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Warfarin: increased anticoagulant effect leading to bleeding risk.
  • Cyclosporine: elevated ivermectin concentrations causing toxicity.

Moderate Interactions (Monitor Closely)

  • Macrolide antibiotics (e.g., erythromycin): may increase ivermectin levels.
  • Anticonvulsants (e.g., carbamazepine): may reduce ivermectin efficacy.
  • HIV protease inhibitors (e.g., ritonavir): may raise ivermectin exposure.

Frequently Asked Questions

Ivermectin Exeltis is prescribed for several parasitic infections, including onchocerciasis (river blindness), strongyloidiasis (intestinal threadworm infection), cutaneous larva migrans (skin migration of hookworm larvae), and scabies caused by the Sarcoptes scabiei mite. These conditions are typically managed in patients who have been diagnosed by a healthcare professional.

Ivermectin acts by binding to glutamate‑gated chloride channels that are unique to many invertebrate parasites. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarizes the parasite’s nerve or muscle cells. The resulting paralysis prevents the parasite from feeding or moving, leading to its death while sparing human cells that lack these specific channels.

The exact dose of Ivermectin Exeltis is determined by the prescribing clinician based on the specific indication, the patient’s body weight, age, and overall health status. Dosage regimens differ for onchocerciasis, strongyloidiasis, cutaneous larva migrans, and scabies, and the prescriber will follow approved guidelines or local practice standards.

Safety data for Ivermectin Exeltis in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative treatments or risk‑benefit considerations with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Ivermectin Exeltis. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Ivermectin Exeltis offers a broad spectrum of activity against several nematodes and ectoparasites, often requiring a single dose for conditions like onchocerciasis and scabies. Compared with albendazole or mebendazole, ivermectin may be more effective for certain skin‑related migrations and for microfilarial infections, though combination therapy is sometimes used to enhance efficacy or prevent resistance.

Ivermectin Exeltis should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging to protect it from moisture, light, and humidity. Do not store in areas with excessive heat or direct sunlight, and keep it out of reach of children.

Ivermectin Exeltis is taken orally, usually with a full glass of water. Depending on the indication, it may be taken with or without food; the prescribing information will specify any particular requirements. The tablet (or other oral form) should be swallowed whole and not chewed or crushed unless directed by a healthcare professional.

While most patients tolerate Ivermectin Exeltis well, serious adverse events can include severe skin reactions such as Stevens‑Johnson syndrome, liver injury manifested by elevated enzymes or hepatitis, and neurologic effects like seizures or altered consciousness. Any signs of these reactions require immediate medical attention and discontinuation of the drug.

Ivermectin Exeltis should be avoided in individuals with known hypersensitivity to ivermectin or any of the product’s excipients. Patients with severe hepatic impairment should not use it without specialist advice. It is also contraindicated in children weighing less than 15 kg for certain indications, and caution is advised in pregnant or nursing women when safer alternatives exist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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