Product image of Ivermectin Orifarm (Ivermectin) supplied by GNH India

Ivermectin Orifarm

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectin Orifarm (Ivermectin)

Ivermectin, the active ingredient in Ivermectin Orifarm, is an anthelmintic (macrocyclic lactone) presented as an oral formulation for oral use. It treats parasitic infections such as onchocerciasis, strongyloidiasis, lymphatic filariasis and scabies in appropriate patients.

GNH India supplies Ivermectin Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

  • Ivermectin is an antiparasitic agent used to treat infections caused by nematodes and ectoparasites.
  • Onchocerciasis: reduces microfilarial load and prevents disease progression.
  • Strongyloidiasis: eliminates intestinal larvae and prevents hyperinfection.
  • Lymphatic filariasis: lowers circulating microfilariae, aiding control programs.
  • Scabies: eradicates Sarcoptes scabiei mites, relieving skin symptoms.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels in invertebrate nerve and muscle cells, increasing chloride ion influx. This hyperpolarises the cells, causing paralysis and death of the parasite. Mammalian cells lack these channels, providing a wide safety margin. After oral absorption, the drug distributes to tissues where parasites reside, exerting its antiparasitic effect.

Side Effects

Ivermectin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools.
  • Dizziness: transient light‑headedness.
  • Pruritus: skin itching at sites of parasite death.

Serious or Rare Side Effects

  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Neurological events: seizures, encephalopathy, or ataxia.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.

Precautions & Warnings

When prescribing Ivermectin, clinicians should consider several safety aspects.

  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Breastfeeding: limited data; weigh potential infant exposure against maternal benefit.
  • Renal impairment: use with caution; monitor if possible.
  • Strong CYP3A4 inhibitors: may increase exposure; adjust therapy as needed.
  • Drug interactions: review concomitant medications for additive toxicity.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Ivermectin can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may markedly increase ivermectin plasma concentrations.
  • P‑glycoprotein inhibitors (e.g., verapamil): can raise systemic exposure.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect; monitor INR.
  • Anticonvulsants (e.g., carbamazepine): may reduce ivermectin levels.
  • Other antiparasitics (e.g., albendazole): potential additive toxicity; assess clinical need.

Frequently Asked Questions

Ivermectin Orifarm is indicated for the treatment of onchocerciasis, strongyloidiasis, lymphatic filariasis and scabies. In each case the drug works to eliminate the causative parasites, reducing symptoms and preventing disease progression when prescribed by a qualified healthcare professional.

Ivermectin binds to glutamate‑gated chloride channels that are present on the nerve and muscle cells of many invertebrates. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarises the cells, leading to paralysis and death of the parasite while sparing mammalian cells that lack these channels.

The dosage of Ivermectin Orifarm is determined by the prescribing clinician based on the specific indication, patient weight, age, and clinical condition. Healthcare providers follow established guidelines and adjust the regimen as needed for each individual case.

Safety data for Ivermectin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Ivermectin belongs to the macrocyclic lactone class and offers a broad spectrum against several nematodes and ectoparasites. Compared with older agents such as albendazole, it often requires a single dose for many indications, providing convenient administration, though choice of therapy depends on the specific parasite, resistance patterns and patient factors.

Ivermectin Orifarm should be stored at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Ivermectin Orifarm is taken orally, usually as a tablet or capsule, with water. The exact administration instructions, including whether it should be taken with food, are provided by the prescribing clinician and should be followed precisely.

Serious adverse events, although rare, can include severe skin reactions such as Stevens‑Johnson syndrome, neurological complications like seizures or encephalopathy, and significant liver injury. Patients should seek immediate medical attention if they experience rash, neurological symptoms, or signs of liver dysfunction.

Ivermectin Orifarm is contraindicated in individuals with known hypersensitivity to ivermectin or any component of the formulation. Caution is also advised for patients with severe hepatic impairment, and it should be avoided in pregnant women unless the therapeutic benefit justifies the potential risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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