Product image of Ivermectin Orifarm (Ivermectin) supplied by GNH India

Ivermectin Orifarm

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectin Orifarm (Ivermectin)

Ivermectin, the active ingredient in Ivermectin Orifarm, is an anthelmintic presented as an oral tablet for oral use. It treats a range of parasitic infections in humans, including onchocerciasis, strongyloidiasis, scabies, lymphatic filariasis and other helminth infections.

GNH India supplies Ivermectin Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Ivermectin is an antiparasitic agent used to treat infections caused by various helminths and ectoparasites.

  • Onchocerciasis: reduces microfilarial load and helps prevent disease progression.
  • Strongyloidiasis: eliminates intestinal larvae and prevents disseminated infection.
  • Scabies: eradicates the Sarcoptes scabiei mite, relieving itching and skin lesions.
  • Lymphatic filariasis: decreases adult worm burden and interrupts transmission.
  • Other helminth infections: provides broad‑spectrum activity against susceptible nematodes.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels found in the nerve and muscle cells of parasites. This binding increases the permeability of the cell membrane to chloride ions, leading to hyperpolarization, paralysis, and ultimately death of the parasite without affecting mammalian cells that lack these channels.

Side Effects

Ivermectin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools, usually transient.
  • Dizziness: occasional light‑headedness.
  • Pruritus: itching that may be related to parasite die‑off.
  • Fatigue: feeling of tiredness.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Neurological events: seizures, encephalopathy, or ataxia.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Hypersensitivity: anaphylaxis or angioedema.
  • Cardiac arrhythmias: rare conduction disturbances.

Precautions & Warnings

Before prescribing Ivermectin, consider patient‑specific factors and safety measures.

  • Pregnancy: use only if the potential benefit outweighs the risk, as safety data are limited.
  • Breastfeeding: weigh benefits against potential infant exposure through milk.
  • Liver impairment: monitor hepatic function and adjust therapy if needed.
  • Concomitant CNS depressants: observe for enhanced central nervous system effects.
  • Drug interactions: review all concurrent medications for potential interactions.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ivermectin may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase ivermectin plasma levels.
  • P‑glycoprotein inhibitors (e.g., verapamil): can raise systemic exposure.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): monitor coagulation parameters.
  • CNS depressants (e.g., benzodiazepines): watch for additive sedation.
  • Other antiparasitics: assess cumulative toxicity risk.

Frequently Asked Questions

Ivermectin Orifarm is indicated for several parasitic infections, including onchocerciasis, strongyloidiasis, scabies, lymphatic filariasis and other helminth infections. It works by targeting the parasites’ nervous system, leading to their paralysis and death, thereby clearing the infection.

Ivermectin binds to glutamate‑gated chloride channels that are present in the nerve and muscle cells of many parasites. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarizes the cells, causing paralysis and eventual death of the parasite while sparing human cells.

The dosage of Ivermectin Orifarm is determined by the prescribing clinician based on the specific infection, patient weight, age, and clinical condition. Healthcare professionals follow established guidelines and adjust the regimen to achieve optimal therapeutic outcomes.

Safety data for ivermectin in pregnancy are limited, so it should only be used when the potential benefit justifies any possible risk to the fetus. During breastfeeding, the decision should consider the benefit to the mother versus potential exposure to the infant through breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivermectin offers a broad spectrum of activity against many nematodes and ectoparasites, often with a single dose regimen, which can be advantageous over drugs requiring multiple daily doses. Compared with alternatives such as albendazole or praziquantel, ivermectin may have a different safety profile and is preferred for specific infections like onchocerciasis and scabies.

Ivermectin Orifarm should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and extreme heat to maintain potency throughout its shelf life.

Ivermectin Orifarm is taken orally, usually as a single tablet or as directed by a healthcare professional. The tablet should be swallowed whole with water, and the exact timing relative to meals depends on the prescriber’s instructions.

Serious adverse events, though rare, can include severe skin reactions such as Stevens‑Johnson syndrome, neurological complications like seizures or encephalopathy, and significant liver injury. Patients should seek immediate medical attention if they experience rash, swelling, difficulty breathing, or neurological symptoms.

Ivermectin Orifarm is contraindicated in individuals with known hypersensitivity to ivermectin or any of its excipients. Caution is also advised for patients with severe liver disease, those taking strong CYP3A4 inhibitors, and pregnant women unless the therapeutic benefit outweighs potential risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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