Product image of Ivermectin Orion (Ivermectin) supplied by GNH India

Ivermectin Orion

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectin Orion (Ivermectin)

Ivermectin, the active ingredient in Ivermectin Orion, is an anthelmintic presented as an oral tablet for oral use. It treats a range of parasitic infections such as onchocerciasis, strongyloidiasis, scabies, lymphatic filariasis and other intestinal helminth infections.

GNH India supplies Ivermectin Orion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

Ivermectin is an antiparasitic agent used to treat infections caused by various helminths and ectoparasites.

  • Onchocerciasis: reduces microfilarial load and prevents disease progression.
  • Strongyloidiasis: eliminates intestinal larvae and prevents hyperinfection.
  • Scabies: eradicates Sarcoptes mites and resolves skin lesions.
  • Lymphatic filariasis (as part of combination therapy): contributes to microfilariae clearance.
  • Other intestinal helminth infections: treats a variety of nematode infections.

How It Works

  • Ivermectin binds selectively to glutamate‑gated chloride channels present in many parasites. This binding increases the influx of chloride ions, causing hyperpolarization of the parasite’s nerve and muscle cells, leading to paralysis and eventual death of the organism.

Side Effects

Ivermectin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea
  • Dizziness
  • Diarrhea
  • Abdominal pain

Serious or Rare Side Effects

  • Severe skin rash or Stevens‑Johnson syndrome
  • Hepatotoxicity
  • Neutropenia
  • Anaphylactic reactions

Precautions & Warnings

Before prescribing Ivermectin, clinicians should consider several safety aspects.

  • Contraindications: avoid in patients with known hypersensitivity to ivermectin.
  • Liver function: monitor hepatic enzymes in patients with pre‑existing liver disease.
  • Co‑infection: evaluate for loiasis before treatment in endemic areas.
  • Elderly patients: use with caution due to potential increased sensitivity.
  • Pregnancy and breastfeeding: assess risk‑benefit ratio as safety data are limited.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ivermectin may interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase ivermectin plasma levels.
  • Warfarin: concurrent use may enhance anticoagulant effect and bleeding risk.
  • P‑glycoprotein inhibitors (e.g., verapamil): can raise systemic exposure.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin): may reduce ivermectin efficacy.
  • Other antiparasitic agents: may increase gastrointestinal adverse effects.

Frequently Asked Questions

Ivermectin Orion is prescribed for several parasitic diseases, including onchocerciasis (river blindness), strongyloidiasis, scabies, lymphatic filariasis when used in combination therapy, and various other intestinal helminth infections. It works by targeting the parasites responsible for these conditions.

Ivermectin binds to glutamate‑gated chloride channels that are found in many invertebrate parasites. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarizes nerve and muscle cells, leading to paralysis and death of the parasite.

The dosage of Ivermectin Orion is determined by the prescribing clinician based on the specific indication, patient weight, age, and clinical condition. Only a qualified healthcare professional should set the appropriate regimen.

Safety data for Ivermectin Orion in pregnancy and lactation are limited. The drug should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified prescriber.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ivermectin Orion belongs to the anthelmintic class and is distinguished by its broad spectrum against both nematodes and ectoparasites. Compared with benzimidazoles, it often requires fewer doses and has a different safety profile, making it a preferred option for certain infections such as onchocerciasis.

Ivermectin Orion should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ivermectin Orion is taken orally, usually as a single dose or a short course, depending on the indication. The tablets should be swallowed whole with water and can be taken with or without food, unless the prescriber advises otherwise.

Serious adverse reactions, although rare, include severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity, neutropenia, and anaphylaxis. Patients should be monitored for any signs of these events and seek immediate medical attention if they occur.

Ivermectin Orion is contraindicated in individuals with a known hypersensitivity to ivermectin or any of its excipients. Caution is also advised for patients with severe liver disease, and it should not be used in patients with loiasis in endemic areas without proper evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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