Product image of Ivermectin Ratiopharm (Ivermectin) supplied by GNH India

Ivermectin Ratiopharm

Active Ingredient:
Ivermectin
Origin:
EU

Ivermectin Ratiopharm (Ivermectin)

Ivermectin, the active ingredient in Ivermectin Ratiopharm, is an anthelmintic presented as an oral tablet for oral use. It treats a range of parasitic worm infections and ectoparasitic infestations, including onchocerciasis, strongyloidiasis, scabies, and lymphatic filariasis, in adults and children as prescribed by a healthcare professional.

GNH India supplies Ivermectin Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, with robust quality‑assurance processes and regulatory compliance across EU and global markets, ensuring consistent product availability and support for healthcare providers.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Ivermectin is an anthelmintic that targets parasitic nematodes and ectoparasites, providing therapeutic benefit in several helminthic and mite‑related diseases.

  • Onchocerciasis: reduces microfilarial load and prevents disease progression.
  • Strongyloidiasis: eradicates intestinal Strongyloides stercoralis infection.
  • Scabies: eliminates Sarcoptes scabiei infestation and relieves itching.
  • Lymphatic filariasis: clears filarial worms and helps interrupt transmission.
  • Other helminth infections: treats various nematode infections such as ascariasis and hookworm.

How It Works

  • Ivermectin binds to glutamate‑gated chloride channels in the nerve and muscle cells of invertebrates. Activation of these channels increases chloride ion influx, causing hyperpolarization of the cell membrane, leading to paralysis and death of the parasite. The drug has low affinity for mammalian receptors, which limits toxicity in humans. It is metabolized primarily in the liver and excreted in feces, with a half‑life of approximately 12–36 hours in humans.

Side Effects

Adverse reactions to Ivermectin are generally mild but can include more serious events in rare cases.

Common Side Effects

  • Nausea: mild stomach upset often reported.
  • Diarrhea: loose stools occurring after dosing.
  • Dizziness: transient light‑headedness.
  • Pruritus: skin itching unrelated to parasitic infection.
  • Fatigue: feeling of tiredness.

Serious or Rare Side Effects

  • Hypersensitivity reactions: rash, swelling, or anaphylaxis.
  • Neurological signs: seizures, ataxia, or altered consciousness.
  • Hepatotoxicity: elevated liver enzymes.
  • Visual disturbances: blurred vision or optic neuritis.

Precautions & Warnings

Before prescribing Ivermectin, clinicians should consider several precautionary measures to ensure safe use.

  • Indication verification: confirm diagnosis of a susceptible parasitic infection.
  • Age restrictions: use only in patients for whom safety has been established, typically children above a certain weight.
  • Liver function: assess hepatic impairment as metabolism may be reduced.
  • Concomitant CNS drugs: avoid co‑administration with medications that lower seizure threshold.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and light.

Avoid Interactions

Ivermectin may interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: such as rifampicin, may reduce ivermectin plasma levels.
  • P‑glycoprotein inhibitors: like verapamil, can increase ivermectin exposure.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: monitor for enhanced bleeding risk.
  • CNS depressants: observe for additive central nervous system effects.
  • Other antiparasitics: assess for cumulative toxicity.

Frequently Asked Questions

Ivermectin Ratiopharm is indicated for several parasitic diseases, including onchocerciasis (river blindness), strongyloidiasis, scabies, lymphatic filariasis, and other helminth infections such as ascariasis and hookworm. It is prescribed by qualified healthcare professionals to eliminate the causative parasites and alleviate associated symptoms.

Ivermectin acts by binding to glutamate‑gated chloride channels in the nerve and muscle cells of invertebrate parasites. This binding opens the channels, allowing an influx of chloride ions, which hyperpolarizes the cell membrane, leading to paralysis and death of the parasite. Human cells lack these specific channels, which limits toxicity.

The appropriate dose of Ivermectin Ratiopharm is determined by the prescribing clinician based on the specific infection, patient weight, age, and overall health status. Dosage regimens can vary between indications, and the prescriber follows current clinical guidelines and product labeling to set the exact amount.

Safety data for ivermectin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians must evaluate each case individually and discuss potential risks with the patient before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Ivermectin Ratiopharm. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details, and any necessary import documentation.

Ivermectin is a broad‑spectrum anthelmintic with a unique mechanism targeting glutamate‑gated chloride channels, which differs from drugs like albendazole that inhibit microtubule formation. It is often preferred for infections such as onchocerciasis and scabies due to its efficacy and convenient single‑dose regimen, while other agents may be chosen based on parasite type or resistance patterns.

Ivermectin Ratiopharm should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture, light, and excessive heat. Do not store in the refrigerator or freezer, as this could affect product stability.

The medication is taken orally, usually as a single tablet or as directed by the prescriber. It should be swallowed with water on an empty stomach unless the product label specifies otherwise. The exact administration schedule depends on the diagnosed condition and the clinician’s instructions.

Serious adverse events, although rare, can include severe hypersensitivity reactions such as anaphylaxis, neurological complications like seizures or ataxia, and liver injury indicated by elevated enzymes. Patients should be monitored for any unusual symptoms, and immediate medical attention is required if severe reactions occur.

Ivermectin should be avoided in individuals with known hypersensitivity to the drug, those with severe liver impairment, and patients taking medications that strongly induce CYP3A4 or inhibit P‑glycoprotein without medical supervision. Pregnant or breastfeeding women should only use it when the potential benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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